Publications by authors named "Brian Coyne"
Article Synopsis
- The study evaluates the effectiveness of a new 6-minute incremental step test (6MIST) combined with portable devices as a simpler alternative to the traditional cardiopulmonary exercise test (CPET) for assessing cardiorespiratory fitness (CRF).
- Researchers enrolled 15 patients who underwent both the 6MIST and standard CPET, recording various CRF-related metrics with wearable technology during the tests.
- The results showed a strong correlation between the measurements from both tests for several CRF parameters; however, there was a weak correlation for cardiac index, indicating that while the 6MIST could be promising, it's not a complete substitute for CPET in measuring all aspects of cardiac function.
Background Splanchnic nerve modulation (SNM) is an emerging procedure to reduce cardiac filling pressures in heart failure. Although the main contributor to reduction in cardiac preload is thought to be increased venous capacitance in the splanchnic circulation, supporting evidence is limited. We examined changes in venous capacitance surrogates pre- and post-SNM.
View Article and Find Full Text PDFAs robotic prostatectomy surgery becomes more prevalent, it is important to identify any regional techniques to optimize patient's recovery. We evaluated the effectiveness of bilateral transversus abdominis plane (TAP) and rectus sheath (RS) blocks with liposomal bupivacaine. We hypothesized that these blocks would reduce perioperative opioid use and pain scores.
View Article and Find Full Text PDFBackground: Androgen deprivation therapy (ADT) and androgen receptor signaling inhibitors (ARSI) are associated with deleterious physical effects, which exercise may mitigate; however, exercise has never been studied in patients initiating treatment with ADT and an ARSI. Our objective was to determine whether supervised exercise prior to and during initial therapy could mitigate adverse effects of ADT plus enzalutamide.
Methods: We conducted a single center trial in patients with recurrent prostate cancer treated with ADT and enzalutamide.
Objectives: We hypothesized that splanchnic nerve blockade (SNB) would attenuate increased exercise-induced cardiac filling pressures in patients with chronic HF.
Background: Chronic heart failure (HF) is characterized by limited exercise capacity driven in part by an excessive elevation of cardiac filling pressures.
Methods: This is a prospective, open-label, single-arm interventional study in chronic HF patients.
Importance: Patients with abnormal (positive) exercise electrocardiography, but normal stress echocardiography (+ECG/-Echo) are commonly encountered in clinical practice; however, the prognostic significance of this discordant result is unclear.
Objective: To determine whether patients with +ECG/-Echo have a higher rate of adverse clinical events and a poorer prognosis than patients with negative exercise ECG and normal stress Echo imaging (-ECG/-Echo).
Design, Setting, And Participants: Between January 1, 2000, and February 28, 2014, a total of 47 944 consecutive patients without known coronary artery disease who underwent exercise stress Echo at Duke University Medical Center were evaluated for inclusion in this observational cohort study.