Docetaxel-Induced Pneumonitis in a Patient With Metastatic Lung Adenocarcinoma.

Docetaxel is a taxane anti-neoplastic agent commonly used in the treatment of solid-organ tumours. Here, we describe a case of a patient with metastatic lung adenocarcinoma who had disease progression following initial treatment with a combination of pembrolizumab, pemetrexed and carboplatin. She received three cycles of docetaxel and had a favourable oncological response but was admitted for breathlessness following the third cycle.

Elevated activated partial thromboplastin time-based clot waveform analysis markers have strong positive association with acute venous thromboembolism.

Introduction: A hypercoagulable state is a predisposition for venous thromboembolism (VTE). The activated partial thromboplastin time (aPTT)-based clot waveform analysis (CWA) is a global haemostatic measure but its role in assessment of hypercoagulability and thrombotic disorders is uncertain. We aimed to study the changes of CWA parameters in acute VTE.

Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease.

The spread of neurodegeneration through the human brain network is reported as underlying the progression of neurodegenerative disorders. However, the exact mechanisms remain unknown. The human visual pathway is characterized by its unique hierarchical architecture and, therefore, represents an ideal model to study trans-synaptic degeneration, in contrast to the complexity in neural connectivity of the whole brain.

A Deep Learning-Based Algorithm Identifies Glaucomatous Discs Using Monoscopic Fundus Photographs.

Purpose: To develop and test the performance of a deep learning-based algorithm for glaucomatous disc identification using monoscopic fundus photographs.

Design: Fundus photograph database study.

Participants: Four thousand three hundred ninety-four fundus photographs, including 3768 images from previous Sydney-based clinical studies and 626 images from publicly available online RIM-ONE and High-Resolution Fundus (HRF) databases with definitive diagnoses.

SUCCESSFUL CLOSURE OF FULL-THICKNESS MACULAR HOLES SECONDARY TO MACULAR VITELLIFORM LESIONS.

Purpose: To describe the first reported cases of full-thickness macular holes secondary to vitelliform lesions that were successfully closed with vitrectomy surgery and gas tamponade.

Methods: Two female patients developed visual loss secondary to bilateral vitelliform lesions and associated full-thickness macular holes. The patients underwent 25-gauge pars plana vitrectomy, internal limiting membrane peeling, and 26% sulfur hexafluoride gas, followed by 3 days of face-down positioning.

Incidence of Intraocular Pressure Elevation following Intravitreal Ranibizumab (Lucentis) for Age-related Macular Degeneration.

Aim: The aim of this article is to evaluate the rate of patients developing sustained elevated intraocular pressure (IOP) after ranibizumab (Lucentis) intravitreal (IVT) injections.

Design: This is a retrospective study.

Participants: Charts of 192 consecutive patients receiving Lucentis for age-related macular degeneration (AMD) were retrospectively reviewed.

Does Chronic Hypotony following Trabeculectomy Represent Treatment Failure?

Purpose: To measure the rate of complications from chronic hypotony following trabeculectomy and clarify the definition of postoperative hypotony.

Materials And Methods: In this retrospective case-control study, the rate of complications was compared between 34 eyes with chronic hypotony and 34 eyes without hypotony. Chronic hypotony was defined as those eyes with an intraocular pressure (IOP) of less than 6 mm Hg on two consecutive clinic visits at least 3 months after trabeculectomy.

Bleb vascularity following post-trabeculectomy subconjunctival bevacizumab: a pilot study.

Background: To determine whether postoperative subconjunctival bevacizumab significantly alters bleb vascularity.

Design: A randomized, prospective interventional study.

Participants: Forty-three eyes from 39 patients were recruited, with 21 eyes randomized to subconjunctival injections of 5-fluorouracil, and 22 eyes to combined 5-fluorouracil/bevacizumab.

Bilateral homonymous superior quadrantanopia after traumatic attempts to remove a cockroach impacted in the external auditory canal.

Visual field defects typically caused by lesions in the optic nerve or optic chiasm may be caused indirectly by subdural haematomas. A 61-year-old man survived transtentorial herniation caused by subdural haematomas that resulted from shaking his head in an attempt to remove a cockroach impacted in his external auditory canal. Bilateral incomplete posterior cerebral artery infarction of both inferior tips of the occipital lobe resulted in bilateral superior quadrantanopia.

Glaucoma prevalence in Indigenous Australians.

Aim: Define the prevalence of glaucoma within the Indigenous Australian population.

Methods: Aboriginal and Torres Strait Islander adults aged ≥ 40 years were recruited from 30 randomly selected sample areas or communities. Participants were regarded to have glaucoma if they had a cup:disc ratio (CDR) of > 0.

A geometric morphometric assessment of the optic cup in glaucoma.

The morphologic appearance of the optic disc is of interest in glaucoma. In contrast to descriptive classification systems that are currently used, a quantitative approach to the analysis of optic disc morphology is required. Our goal was to determine the optimal method for quantifying optic cup shape by comparing traditional (ovality, form-factor and neuroretinal rim (NRR) width ratio) and geometric morphometric approaches.

Positive association between plasma homocysteine level and chronic kidney disease.

Background: Increasing experimental evidence, including recently developed animal models, supports a role for homocysteine in the development of chronic kidney disease (CKD). However, relatively few clinical/epidemiological studies have examined this hypothesis in humans. We examined the relationship between plasma homocysteine level and CKD in a population-based study of older Australians.

Optical coherence tomography findings of acute traumatic maculopathy following motor vehicle accident.

Purpose: To describe two cases of acute traumatic maculopathy using optical coherence tomography (OCT) following high-speed motor vehicle accidents.

Design: Case reports.

Methods: Patients were examined soon after the accident using Snellen visual acuity (VA), dilated fundus examination, and OCT.

Homocysteine and retinal emboli: the Blue Mountains Eye Study.

Purpose: To examine the association between serum homocysteine and retinal emboli in a general older population.

Design: Cross-sectional population-based study.

Methods: Homocysteine level was determined from fasting venous blood collection at the second Blue Mountains Eye Study (BMES) (n = 3509, age > or =49 years, 1997 to 2000).

Dietary fatty acids and the 5-year incidence of age-related maculopathy.

Objective: To assess longitudinal associations between dietary fat and incident age-related maculopathy (ARM) in an older, population-based, historical cohort.

Methods: A total of 3654 persons, 49 years or older, participated in the Blue Mountains Eye Study (1992-1994); 2335 (75.1% of survivors) were reexamined after 5 years (1997-1999).

Retinal vessel diameters and obesity: a population-based study in older persons.

Objective: Obesity is linked with large vessel atherosclerosis and diabetes. Its association with microvascular changes is less clear. We investigated the associations among retinal vessel diameters, vessel wall signs, and BMI in an older population.

Management of Duane retraction syndrome.

Background: Duane retraction syndrome is the most common cause of congenital aberrant ocular innervation. We report referral practices, clinical characteristics and complications, prevalence of congenital and familial anomalies, and management outcomes from a clinic-based series.

Methods: Retrospective clinic-based study of 65 patients with Duane retraction syndrome seen between January 1994 and March 2004.

Homocysteine and retinal vein occlusion: a population-based study.

Purpose: To report population data on the association between homocysteinemia and retinal vein occlusion (RVO).

Design: Cross-sectional, population-based study.

Methods: Total serum homocysteine (tHcy) was estimated in subjects attending the second Blue Mountains Eye Study (BMES) (n = 3509, aged >49 years).

A retrospective review of the associations between amblyopia type, patient age, treatment compliance and referral patterns.

Aim: To review presenting ages, referral sources, amblyopia type and treatment compliance in children attending a typical public hospital ophthalmology clinic with no formal amblyopia screening program in place.

Methods: One hundred and twenty-seven children attending the outpatients clinics of The Children's Hospital at Westmead for amblyopia management between January 2001 and May 2003 were reviewed. Presenting age, amblyopia type, referral source, treatment prescribed and compliance achieved were analysed using means, 95% confidence intervals (CI), and Mantel-Haenszel chi2 statistic.

Corneal arcus and hyperlipidemia: findings from an older population.

Purpose: To quantify the association between arcus and hyperlipidemia in an older population.

Design: Cross-sectional population-based study.

Methods: Arcus and serum lipids were measured in the Blue Mountains Eye Study (n = 3,654, aged >49 years).