Publications by authors named "Brian Bolton"
Article Synopsis
- There is increasing interest in multifunctional drug delivery systems, particularly composite nanodevices (CNDs), which can be used for diagnosing and treating diseases like cancer.
- The study investigates how the size and surface charge of gold-dendrimer CNDs influence their behavior in mouse tumor models, specifically focusing on biodistribution and excretion patterns.
- Findings reveal that both size and surface charge significantly impact where these CNDs accumulate in the body, suggesting potential for tailored nanodevice design for targeted medical applications.
Combination tetrathiomolybdate and radiation therapy in a mouse model of head and neck squamous cell carcinoma.
Arch Otolaryngol Head Neck Surg
March 2006
Objective: To assess the effect of combining tetrathiomolybdate therapy and radiation treatment (RT) on tumor growth in the mouse head and neck squamous cell carcinoma (HNSCC) model.
Design: One million HNSCC cells were injected subcutaneously into the flanks of C3H/HeJ mice and the tumors grown to an average of 301 mm3 (day 0). Mice were randomized into 4 groups: (a) no therapy, (b) tetrathiomolybdate alone, (c) RT alone, or (d) tetrathiomolybdate + RT.