Publications by authors named "Brewer L"

Study Objectives: A non-intrusive sleep monitoring technology based on the data from a commercially available depth sensing camera has been utilized for respiratory monitoring and shown to have good performance in assessing respiratory rates across a range of rates. This non-contact, or , technology allows continuous respiratory monitoring without attaching probes to the patient. We have noticed a strikingly similar morphology between the touchless flow signal (NCM) and the flow signal derived using the chest and abdomen respiratory inductance plethysmography (RIP) bands.

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Background: African Americans have a higher prevalence of cardiovascular risk factors, leading to higher cardiovascular disease mortality than White adults. Our culturally tailored mobile health (mHealth) lifestyle intervention () has previously demonstrated efficacy in promoting ideal cardiovascular health in African Americans.

Methods: We conducted a secondary analysis from a cluster randomized controlled trial among African-Americans from 16 churches in Minnesota that compared the to a delayed intervention control group.

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  • The study investigated the link between predelivery cardiology care and major adverse cardiovascular events (MACE) in Black and White patients with Preeclampsia/Eclampsia (PrE/E), using data from 29,336 patients delivered between 2008 and 2019.
  • Findings revealed that Black patients experienced a higher cumulative incidence of MACE within a year post-delivery compared to White patients, particularly in the first 14 days.
  • Predelivery cardiology care reduced the risk of MACE for White patients shortly after delivery, but did not have a significant impact for Black patients during the same period.
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Creating statistically equivalent virtual microstructures (SEVM) for polycrystalline materials with complex microstructures that encompass multi-modal morphological and crystallographic distributions is a challenging enterprise. Cold spray-formed (CSF) AA7050 alloy containing coarse-grained prior particles and ultra-fine grains (UFG) and additively manufactured (AM) Ti64 alloys with alpha laths in beta substrates. The paper introduces an approach strategically integrating a Generative Adversarial Network (GAN) for multi-modal microstructures with a synthetic microstructure builder DREAM.

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  • * Researchers combined techniques like cryo-electron microscopy (cryo-EM), crosslinking mass spectrometry (XL-MS), and AlphaFold2 predictions to create a model of the NER pre-incision complex (PInC), highlighting how proteins interact during DNA repair.
  • * The study reveals new insights into how specific proteins (like TFIIH, XPG, and XPF) coordinate their actions, affects DNA binding, and provides explanations for disease-causing mutations related to xeroderma pigmentosum and Cockayne syndrome.
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The science of cardiac rehabilitation and the secondary prevention of cardiovascular disease has progressed substantially since the most recent American Heart Association and American Association of Cardiovascular and Pulmonary Rehabilitation update on the core components of cardiac rehabilitation and secondary prevention programs was published in 2007. In addition, the advent of new care models, including virtual and remote delivery of cardiac rehabilitation services, has expanded the ways that cardiac rehabilitation programs can reach patients. In this scientific statement, we update the scientific basis of the core components of patient assessment, nutritional counseling, weight management and body composition, cardiovascular disease and risk factor management, psychosocial management, aerobic exercise training, strength training, and physical activity counseling.

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Background: African-American (AA) women are less likely to achieve ideal cardiovascular (CV) health compared with women of other racial/ethnic subgroups, primarily due to structural and psychosocial barriers. A potential psychosocial construct relevant to ideal CV health is the superwoman schema (SWS).

Purpose: We explored whether the SWS was associated with perceived stress, CV risk factors, and overall CV health among AA women.

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Background: Individuals living in rural communities experience substantial geographic and infrastructure barriers to attaining health equity in accessing tobacco use cessation treatment. Social media and other digital platforms offer promising avenues to improve access and overcome engagement challenges in tobacco cessation efforts. Research has also shown a positive correlation between faith-based involvement and a lower likelihood of smoking, which can be used to engage rural communities in these interventions.

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Background: Ataxic breathing (AB) is a well-known manifestation of opioid effects in animals and humans, but is not routinely included in monitoring for opioid-induced respiratory depression (OIRD). We quantified AB in normal volunteers receiving increasing doses of remifentanil. We used a support vector machine (SVM) learning approach with features derived from a modified Poincaré plot.

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  • - The study examined gender representation in clinical trials for FDA-approved anticancer drugs from 1998-2018, focusing on participation rates of women compared to men across various cancer types.
  • - Findings indicated that women constituted only 40.7% of participants in 148 trials, with significant under-representation in trials for gastric, liver, and lung cancers, while sex-specific efficacy and safety data were rarely reported (only 4% of trials).
  • - Despite low female enrollment, there was no correlation between the percentage of women recruited and drug efficacy, highlighting a persistent gap in gender representation in cancer research.
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Objective: To describe perceptions of supportive factors for reducing the risk of maternal mortality among women with substance use disorders (SUDs) in a rural setting.

Design: Qualitative descriptive design.

Setting/local Problem: Participants were recruited from a rural setting in a U.

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  • * It analyzes data from the Atherosclerosis Risk in Communities Study, including diverse participants from four US communities, with an average follow-up period of nearly 19 years.
  • * Findings suggest that individuals who lived in lower SES neighborhoods during middle adulthood had a significantly higher risk of dying before age 75 compared to those from higher SES neighborhoods.
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Mammalian placentas exhibit unparalleled structural diversity, despite sharing a common ancestor and principal functions. The bulk of structural studies in placental research has used two-dimensional (2D) histology sectioning, allowing significant advances in our understanding of mammalian placental structure. However, 2D histology sectioning may be limited if it does not provide accurate information of three-dimensional (3D) tissue architecture.

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Cardiovascular diseases (CVDs) are responsible for approximately 35% of all deaths in women. In 2019, the global age-standardized CVD prevalence and mortality of women were 6,403 per 100,000 and 204 per 100,000, respectively. Although the age- and population-adjusted prevalence has decreased globally, opposite trends are evident in regions of socioeconomic deprivation.

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What Is This Summary About?: This summary describes a publication about a study called SPRINT. The SPRINT study included 50 children with neurofibromatosis type 1 (NF1) and plexiform neurofibroma (PN) that could not be removed with surgery. PNs are tumors that grow along nerves and can cause various problems for children, such as pain, changes to appearance, and muscle weakness.

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Background: African Americans (AAs) face cardiovascular health (CVH) disparities linked to systemic racism. The 2020 police killing of Mr. George Floyd in Minneapolis, Minnesota, alongside the COVID-19 pandemic, exacerbated adverse psychosocial factors affecting CVH outcomes among AAs.

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Wheat bran (WB) is a well-known and valuable source of dietary fiber. Arabinoxylan (AX) is the primary hemicellulose in WB and can be isolated and used as a functional component in various food products. Typically, AX is extracted from the whole WB using different processes after mechanical treatments.

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Background: Transcatheter aortic valve replacement (TAVR) are not offered equitably to vulnerable population groups. Adequate levels of insurance may narrow gaps among patients with higher social vulnerability index (SVI). Among a national population of individuals with commercial or Medicare insurance, we sought to determine whether SVI was associated with urgency of receipt of TAVR for aortic stenosis.

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