Publications by authors named "Breuilly M"
Article Synopsis
- The study investigates the role of IL-6 and MCP-1 cytokines, along with the STAT3 signaling pathway, in recruiting and activating macrophages during heart attacks (STEMI) using both human and mouse models.
- Cardiac cells release these cytokines under low oxygen conditions, leading to the activation of anti-inflammatory macrophages through the STAT3 pathway.
- The research finds that blocking IL-6, MCP-1, or the STAT3 pathway can decrease heart damage after a heart attack, suggesting that these anti-inflammatory macrophages may have negative effects in the early stages of STEMI.
Article Synopsis
- - Neutrophilia and a high neutrophil:lymphocyte ratio are common in severe COVID-19, yet how well these neutrophils function is not well studied
- - A new assay showed that neutrophils from severe COVID-19 patients produce significantly more reactive oxygen species (ROS), with levels nine times higher than healthy individuals, especially in patients on mechanical ventilation
- - The findings suggest that while neutrophils are elevated in COVID-19 and sepsis, their ability to generate ROS could provide insights into disease severity and might be a target for new therapies
Computed tomography (CT) is one of the most commonly used clinical imaging modalities. There have recently been many reports of novel contrast agents for CT imaging. In particular, the development of gold nanoparticles (AuNP) as CT contrast agents is a topic of intense interest.
View Article and Find Full Text PDFRespiratory motion can blur the tomographic reconstruction of positron emission tomography or single-photon emission computed tomography (SPECT) images, which subsequently impair quantitative measurements, e.g. in the upper abdomen area.
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