Fructose regulates the pentose phosphate pathway and induces an inflammatory and resolution phenotype in Kupffer cells.

Over-consumption of fructose in adults and children has been linked to increased risk of non-alcoholic fatty liver disease (NAFLD). Recent studies have highlighted the effect of fructose on liver inflammation, fibrosis, and immune cell activation. However, little work summarizes the direct impact of fructose on macrophage infiltration, phenotype, and function within the liver.

Long-lived lunar volcanism sustained by precession-driven core-mantle friction.

Core-mantle friction induced by the precession of the Moon's spin axis is a strong heat source in the deep lunar mantle during the early phase of a satellite's evolution, but its influence on the long-term thermal evolution still remains poorly explored. Using a one-dimensional thermal evolution model, we show that core-mantle friction can sustain global-scale partial melting in the upper lunar mantle until ∼3.1 Ga, thus accounting for the intense volcanic activity on the Moon before ∼3.

Parent-Child Inpatient Treatment in Child and Adolescent Mental Healthcare: Predictors of Child Outcomes.

Family inpatient units in child and adolescent mental health (CAMH) services engage all admitted family members in the treatment of children's symptoms. Studies demonstrated improvements in child and family functioning following family inpatient treatment, but evidence regarding predictors of treatment outcome is lacking. We analyzed data of families (n = 66) who received a four-week inpatient treatment for families with severe parent-child interaction problems.

Exposure to polycyclic aromatic hydrocarbons assessed by biomonitoring of firefighters during fire operations in Germany.

Background: Firefighters are exposed to a variety of hazardous substances including carcinogens such as polycyclic aromatic hydrocarbons (PAH) during firefighting. In order to minimize the uptake of such substances into the body, firefighters wear personal protective equipment. Only few data exist from real-life firefighting missions and under common although highly variable exposure scenarios such as fighting fires in residential buildings, outdoor, and vehicle fires.

Construction of an In Vitro Air-Liquid Interface Exposure System to Assess the Toxicological Impact of Gas and Particle Phase of Semi-Volatile Organic Compounds.

Anthropogenic activities and industrialization render continuous human exposure to semi-volatile organic compounds (SVOCs) inevitable. Occupational monitoring and safety implementations consider the inhalation exposure of SVOCs as critically relevant. Due to the inherent properties of SVOCs as gas/particle mixtures, risk assessment strategies should consider particle size-segregated SVOC association and the relevance of released gas phase fractions.

Estimating cobalt exposure in respirable dust from cobalt in inhalable dust.

Cobalt is a commonly used element in metal industry. Exposure to workers occurs mainly by inhalation of cobalt-containing dust. For the evaluation of cobalt exposure, risk assessment and investigations on occupational diseases, measurements of cobalt in respirable dust are needed.

Prediction of Educational Attainment and Occupational Functioning in Young Adults With a Childhood Diagnosis of ADHD: Results from the Cologne Adaptive Multimodal Treatment (CAMT) Study.

Objective: This longitudinal study examined early predictors of educational attainment and occupational functioning in adults with a childhood diagnosis of attention-deficit/hyperactivity disorder (ADHD).

Method: Participants ( = 70) of the Cologne Adaptive Multimodal Treatment (CAMT) Study were diagnosed with ADHD and received adaptive multimodal ADHD treatment during childhood. They were then followed through adolescence into adulthood.

In vitro genotoxicity of dibutyl phthalate on A549 lung cells at air-liquid interface in exposure concentrations relevant at workplaces.

The ubiquitous use of phthalates in various materials and the knowledge about their potential adverse effects is of great concern for human health. Several studies have uncovered their role in carcinogenic events and suggest various phthalate-associated adverse health effects that include pulmonary diseases. However, only limited information on pulmonary toxicity is available considering inhalation of phthalates as the route of exposure.

Estimating nickel exposure in respirable dust from nickel in inhalable dust.

The conversion of dust components is of high importance for retrospective evaluations of exposure levels, of occupational diseases or the time trend of occupational dust exposure. For this purpose, possibilities to convert nickel concentrations from inhalable to respirable dust are discussed in this study. Therefore, 551 parallel measurements of nickel concentrations in inhalable and respirable dust fractions were extracted from the exposure database MEGA (maintained at the Institute for Occupational Safety and Health of the German Social Accident Insurance) and investigated by linear regression analysis of ln-transformed concentrations.

Does parent management training reduce behavioural and emotional problems in children with intellectual disability? A randomised controlled trial.

Background: Children with intellectual disability (ID) are more likely to develop behavioural and emotional problems. However, specific interventions for the treatment of these problems in children with ID have rarely been evaluated. Parent management training (PMT) has been shown to be effective in reducing behavioural and emotional problems for other mental disorders.

Naphthalene: irritative and inflammatory effects on the airways.

Objective: This cross-sectional study determined whether acute sensory irritative or (sub)chronic inflammatory effects of the eyes, nose or respiratory tract are observed in employees who are exposed to naphthalene at the workplace.

Methods: Thirtynine healthy and non-smoking male employees with either moderate (n = 22) or high (n = 17) exposure to naphthalene were compared to 22 male employees from the same plants with no or only rare exposure to naphthalene. (Sub)clinical endpoint measures included nasal endoscopy, smell sensitivity, self-reported work-related complaints and the intensity of naphthalene odor and irritation.

Predicting delinquent behavior in young adults with a childhood diagnosis of ADHD: results from the Cologne Adaptive Multimodal Treatment (CAMT) Study.

The aim of this study was to investigate which factors predict lifetime reports of delinquent behavior in young adults who had received adaptive multimodal treatment of attention-deficit/hyperactivity disorder (ADHD) starting at ages 6-10 years. Participants were reassessed 13-24 years (M = 17.6, SD = 1.

Children with Attention-Deficit/Hyperactivity Disorder Grown Up: An 18-Year Follow-Up after Multimodal Treatment.

Objective: ADHD treatment has positive effects on behavioral symptoms and psychosocial functioning, but studies that follow children treated for ADHD into adulthood are rare.

Method: This follow-up study assessed symptom severity and functional outcomes of adults ( = 70) who had received individualized ADHD treatment in the Cologne Adaptive Multimodal Treatment (CAMT) Study at ages 6 to 10 years.

Results: Despite symptomatic improvement, participants reported poorer educational and occupational outcomes than expected (e.

Development of a Personal Aerosol Sampler for Monitoring the Particle-Vapour Fractionation of SVOCs in Workplaces.

Semi-volatile organic compounds (SVOCs), partitioned between particulates and vapours of an aerosol, require special attention. The toxicological effects caused by the inhalation of such aerosols may depend on the concentration and in which phase the organic compounds are found. A personal denuder-gas-particle separation aerosol sampler was developed to provide information about the partitioning of aerosols from organic compounds.

A long-lived magma ocean on a young Moon.

A giant impact onto Earth led to the formation of the Moon, resulted in a lunar magma ocean (LMO), and initiated the last event of core segregation on Earth. However, the timing and temporal link of these events remain uncertain. Here, we demonstrate that the low thermal conductivity of the lunar crust combined with heat extraction by partial melting of deep cumulates undergoing convection results in an LMO solidification time scale of 150 to 200 million years.

(Mono-) Exposure to Naphthalene in the Abrasives Industry: Air Monitoring and Biological Monitoring.

Exposure to the bicyclic aromatic hydrocarbon naphthalene occurs in most cases along with other polycyclic aromatic hydrocarbons. Here we report from an investigation of 63 healthy, non-smoking male employees in the abrasives industry where naphthalene is the only relevant chemical exposure. Exposure assessment was performed using a combination of Air and Biological Monitoring over nearly a whole working week (Mo.

Estimating Respirable Dust Exposure from Inhalable Dust Exposure.

In the sector of occupational safety and health only a limited amount of studies are concerned with the conversion of inhalable to respirable dust. This conversion is of high importance for retrospective evaluations of exposure levels or of occupational diseases. For this reason a possibility to convert inhalable into respirable dust is discussed in this study.

Piezoelectric Micro-dosing System for Spiking Quality Samples in Occupational Hygiene Laboratories.

Quality control is crucially important in the arena of chemical analysis. Reference materials are essential for calibration and quality control processes, and for verification of the accuracy and reliability of the analytical results obtained. Owing to the complexity of their manufacture, reference materials for chemical agents occurring at workplaces are expensive and available only on a limited scale and for a small number of substances.

CD8 T cells regulate liver injury in obesity-related nonalcoholic fatty liver disease.

Nonalcoholic steatohepatitis (NASH) has increased in Western countries due to the prevalence of obesity. Current interests are aimed at identifying the type and function of immune cells that infiltrate the liver and key factors responsible for mediating their recruitment and activation in NASH. We investigated the function and phenotype of CD8 T cells under obese and nonobese NASH conditions.

Efficacy of Omega-3/Omega-6 Fatty Acids in Preschool Children at Risk of ADHD: A Randomized Placebo-Controlled Trial.

To evaluate the efficacy of an Omega-3/Omega-6 fatty acid supplement in preschool children at risk for ADHD. Forty preschool children with elevated levels of ADHD symptoms were randomly assigned to either a verum or a placebo group. Children in the verum group received a 4-month treatment with Omega-3/Omega-6 fatty acids.

Comparison of Microwave-Assisted Digestion and Consensus Open-Vessel Digestion Procedures for Evaluation of Metalliferous Airborne Particulate Matter.

Metal occupational exposure limits mainly focus on total content of the respective metals of interest. The methods applied for trace metal analysis in occupational health and safety laboratories are usually standardized to pragmatic consensus digestion schemes, ensuring comparability of results. The objective of the present study entailed the evaluation of a recently developed HNO3-only microwave-assisted digestion procedure by comparison with the German consensus hot-block digestion and other national digestion schemes.

Validity of different biomonitoring parameters in human urine for the assessment of occupational exposure to naphthalene.

Up to date, information on the validity of human biomonitoring (HBM) parameters of naphthalene exposure is poor. This study was performed to reveal the relation between occupational exposure to naphthalene and biological exposure markers. Therefore, ten lowly and highly exposed workers from the abrasives industry were selected to characterise a broad exposure range.

Role of the vacuolar ATPase in the replication cycle.

We have shown that can enter cells by direct penetration at the plasma membrane (R. Vancini, G. Wang, D.

Sampling and Analysis of Bitumen Fumes: Comparison of German and French Methods to Determine a Conversion Formula.

Bitumen is classed as possibly carcinogenic to humans according to the International Agency for Research on Cancer. Data on individual exposure to bitumen fumes is therefore required to highlight the exposing situations and develop methods to prevent them. The Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA) and the French National Research and Safety Institute for the Prevention of Occupational Accidents and Diseases (INRS) have both developed methods to measure individual exposure.

Carbonaceous Monolithic Multi-Channel Denuders as Vapour-Particle Partitioning Tools for the Occupational Sampling of Semi-Volatile Organic Compounds.

Denuders are gas-particle partitioning tools and can be used in combination with filters and adsorbers for phase-separated collection of hazardous semi-volatile organic compound (SVOC) aerosols. Here, we investigated the suitability of carbonaceous monolithic multi-channel denuders for this approach. Particle transmission efficiency through the denuders was investigated using particles of polystyrene latex (PSL) and droplets of n-hexadecane and diethylene glycol.