Publications by authors named "Bretthauer M"
Importance: Patients of physicians with higher adenoma detection rates (ADRs) during colonoscopy have lower colorectal cancer (CRC) risk after screening colonoscopy (ie, postcolonoscopy CRC). Among physicians with an ADR above the recommended threshold, it is unknown whether improving ADR is associated with a lower incidence of CRC in their patients.
Objective: To determine the association of improved ADR in physicians with a range of ADR values at baseline with CRC incidence among their patients.
Article Synopsis
- AI has the potential to improve gastrointestinal endoscopy, but standardized methods are needed for its effective adoption in clinical practice.
- The QUAIDE Explanation and Checklist was created by a panel of 32 experts to provide guidelines for designing and reporting AI studies in this field.
- Consensus was achieved on 18 recommendations across key areas including data collection, outcome reporting, experimental setup, and result presentation, aiming to enhance research consistency and facilitate the use of AI in clinical settings.
Prediction of metachronous advanced colorectal neoplasia by KRAS mutation in polyps.
United European Gastroenterol J
November 2024
Background: The potential of molecular markers in the removed polys as reliable predictors of metachronous lesions is still uncertain.
Aim: Our aim was to evaluate the role of somatic mutations in KRAS in polyps of patients with high-risk adenomas to predict the risk of advanced polyps or colorectal cancer (CRC) within 3 years.
Methods: A total of 518 patients were prospectively enrolled.
Article Synopsis
- A cross-sectional study in Norway examined adverse events related to colonoscopy in a randomized colorectal cancer screening trial, involving over 10,000 participants.
- Out of those, 2.4% experienced adverse events, ranging from mild to severe, with the most common issues being gastrointestinal bleeding and abdominal pain.
- Key risk factors for adverse events included older age, female sex, and specific medical treatments, highlighting the importance of awareness for endoscopists to reduce risks.
Article Synopsis
- Different countries have different rules for how positive results are determined in poop tests for colorectal cancer (CRC) screening.
- In a study with Norwegian people aged 50-74, they looked at the number of colonoscopies (a procedure to check the colon) at various poop test thresholds.
- They found that higher thresholds mean fewer colonoscopies but also less chance of finding serious issues like cancer, and the risk of problems during the colonoscopy increases with higher thresholds.
Background: Colorectal cancer is one of the most common forms of cancer in Norway, and typically develops from colorectal polyps. For benign colorectal polyps, endoscopic removal is recommended to avoid unnecessary surgery. This study identifies the extent of surgical treatment of benign polyps in the period 1 January 2008-31 December 2021.
View Article and Find Full Text PDFBrief sigmoidoscopy provides 21-year colorectal cancer risk reduction in men.
Lancet Gastroenterol Hepatol
September 2024
Article Synopsis
- Pancreatoduodenectomy, the main treatment for pancreatic and periampullary cancers, has serious complications but shows improving outcomes over time.* -
- A study in Sweden followed 5,923 patients from 1964 to 2016, revealing a significant drop in postoperative deaths from 17.2% to 1.6% over the decades.* -
- Survival rates also improved notably; from 2010-2016, 5-year survival rates varied by cancer type, with up to 71.2% for duodenal cancer and 29.0% for pancreatic cancer.*
Advancing patient-centered care: Recent developments in UEG's patient relations.
United European Gastroenterol J
July 2024
Background And Aims: Serrated polyps (SPs) are precursors to 15% to 20% of colorectal cancers (CRCs). However, there are uncertainties regarding which SPs require surveillance and at what intervals, with recommendations adapted from those for adenomas in the absence of solid evidence. Our aim was to assess which SP risk characteristics relate to a higher risk of metachronous CRC or advanced polyps.
View Article and Find Full Text PDFBackground And Study Aims: Long-time follow-up of sigmoidoscopy screening trials has shown reduced incidence and mortality of colorectal cancer (CRC), but inadequate bowel cleansing may hamper efficacy. The aim of this study was to assess the impact of bowel cleansing quality in sigmoidoscopy screening.
Patients And Methods: Individuals 50 to 74 years old who had a screening sigmoidoscopy in a population-based Norwegian, randomized trial between 2012 and 2019, were included in this cross-sectional study.
This article summarizes clinically important gastroenterology developments from 2023 for internal medicine specialists. In colorectal cancer screening, a new RNA fecal screening test is on the horizon, as well as a new analysis on the benefits of using artificial intelligence in screening colonoscopy to detect more polyps. There is new evidence for management of gastrointestinal bleeding, a new drug for treatment of recurrent small-intestinal angiodysplasia, and a new endoscopic treatment method in patients with gastrointestinal tumor bleeding.
View Article and Find Full Text PDFImportance: Randomized clinical screening trials have shown that sigmoidoscopy screening reduces colorectal cancer (CRC) incidence and mortality. Colonoscopy has largely replaced sigmoidoscopy for CRC screening, but long-term results from randomized trials on colonoscopy screening are still lacking.
Objective: To estimate the additional screening benefit of colonoscopy compared with sigmoidoscopy.
Background: The Norwegian Directorate of Health produces national clinical guidelines for the health service, and the development of guidelines must follow international standards for trustworthy clinical practice. We investigated whether the standards are being adhered to.
Material And Method: We used the National Guideline Clearinghouse Extent Adherence to Trustworthy Standards Instrument (NEATS) as the scoring tool and assessed a randomly selected chapter from national clinical guidelines that were published or updated during the period 2013 to January 2022.