Publications by Brett W Ching

Publications by authors named "Brett W Ching"

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Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists.

Joseph R Fotsing Vincent Darmohusodo Andrew P Patron Brett W Ching Thomas Brady

J Med Chem

May 2020

In humans, bitter taste is mediated by 25 TAS2Rs. Many compounds, including certain active pharmaceutical ingredients, excipients, and nutraceuticals, impart their bitter taste (or in part) through TAS2R8 activation. However, effective TAS2R8 blockers that can either suppress or reduce the bitterness of these compounds have not been described.

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- Brett W Ching's research primarily focuses on the discovery and development of pharmacological agents that target taste receptors, particularly the TAS2R8 receptor, which is involved in mediating bitter taste perception in humans.
- His 2020 article titled "Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists" highlights the identification of compounds that effectively block TAS2R8 activation and potentially mitigate bitter taste from certain pharmaceuticals and nutraceuticals.
- The findings underscore the need for effective TAS2R8 antagonists, as existing blockers were previously lacking, paving the way for improving patient compliance with bitter-tasting medications through better formulation strategies.*

Publications by authors named "Brett W Ching"

Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists.

Synopsis of recent research by authors named "Brett W Ching"