Publications by authors named "Brett Roach"
Background: Prognosis of esophageal adenocarcinoma (EAC) is still poor. Therefore, the development of novel therapeutic modalities is necessary to improve therapeutic outcomes in EAC. Here, we report a novel promoter-controlled oncolytic adenovirus targeting CDX2 (Ad5/3-pCDX2) and its specific anticancer effect for EAC.
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- - Changes in mitochondrial shape are linked to how cells utilize nutrients, particularly the process of breaking down fatty acids (FAO), with increased fragmentation leading to higher FAO rates.
- - Forcing mitochondria to elongate decreases FAO, while inducing fragmentation boosts FAO across different cell types, influencing functions like gluconeogenesis and insulin secretion.
- - The study identifies that mitochondrial fragmentation affects the regulation of FAO through the enzyme CPT1, which is influenced by malonyl-CoA levels, highlighting its role in how cells prefer and use different fuel sources.
More than 30% of people in the United States (US) are classified as obese, and over 50% are considered significantly overweight. Importantly, obesity is a risk factor not only for the development of metabolic syndrome but also for many cancers, including pancreatic ductal adenocarcinoma (PDAC). PDAC is the third leading cause of cancer-related death, and 5-year survival of PDAC remains around 9% in the U.
View Article and Find Full Text PDFThis series of 13 articles (7 original articles, 6 reviews) is presented by international leaders in adenovirus-based cancer therapy [...
View Article and Find Full Text PDFCyclin-dependent kinase 5 (CDK5) is a serine/threonine kinase essential for embryonic development whose overactivation has been implicated in several pathologies including neurodegeneration, cancer cell metastasis and type II diabetes. Therefore, it is important to investigate molecular mechanism(s) that mediate regulation of CDK5 activity. Here we identify and characterize a novel phosphoregulatory site on CDK5.
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