Rapid and Versatile Functionalization of Poly-Ethylene Imine via Dynamic Aminal Formation.

The study of dynamic covalent chemistry (DCC) is growing rapidly in polymer chemistry. The dynamic covalent chemistry of polyaminals formed by the reaction of linear polyethyleneimine (L-PEI) with various functional aldehydes is explored. The study demonstrates the pH-dependent kinetics of polyaminal formation and the versatility of polyaminals in controlling the release of aldehydes under ambient conditions.

Polymers from Cellulosic Waste: Direct Polymerization of Levoglucosenone using DBU as a Catalyst.

The bio-based platform molecule levoglucosenone (LGO) is now produced at multi-ton scale by the pyrolysis of cellulosic waste. As such it has become an industrially viable, non-petroleum-derived chemical feedstock. Herein we report the direct (one-step) and operationally simple polymerization of LGO that provides a highly sustainable method for polymer synthesis.

How many days of indoor positioning system data are required to characterise typical movement behaviours of office workers?

Indoor Positioning Systems (IPS) appear to offer great potential to study the movement and interaction of people and their working environment, including office workplaces. But little is known about appropriate durations for data collection. In this study, location observations collected from 24 office workers on a 1220 m office floor over a 3-month period, were analysed to determine how many days are required to estimate their typical movement and spatial behaviours.

Activity space, office space: Measuring the spatial movement of office workers.

A key to the development of more effective interventions to promote movement and reduce physical inactivity in office workplaces may be to measure and locate individual's spatial movement. Using an activity space estimation method, high resolution location data collected from 15 office workers over 12 days were used to estimate and analyse the location and extent of their daily spatial movement whilst in an office work-based setting. The results indicated that the method, kernel density estimation, combined with location data offers significant opportunities to not only measure and compare spatial movement behaviours but also simultaneously identify the locations where the behaviours occur.

Stop motion: using high resolution spatiotemporal data to estimate and locate stationary and movement behaviour in an office workplace.

Prolonged periods of stationary behaviour, a common occurrence in many office workplaces, are linked with a range of physical disorders. Investigating the physical context of this behaviour may be a key to developing effective interventions. This study aimed to estimate and locate the stationary and movement behaviours of office workers ( = 10) by segmenting spatiotemporal data collected over 5 days in an office work-based setting.

Exploiting Nature's Most Abundant Polymers: Developing New Pathways for the Conversion of Cellulose, Hemicellulose, Lignin and Chitin into Platform Molecules (and Beyond).

The four most prominent forms of biomass are cellulose, hemicellulose, lignin and chitin. In efforts to develop sustainable sources of platform molecules there has been an increasing focus on examining how these biopolymers could be exploited as feedstocks that support the chemical supply chain, including in the production of fine chemicals. Many different approaches are possible and some of the ones being developed in the authors' laboratories are emphasised.

Movement at work: A comparison of real time location system, accelerometer and observational data from an office work environment.

Office workers can spend significant periods of time being stationary whilst at work, with potentially serious health consequences. The development of effective health interventions could be aided by a greater understanding of the location and environmental context in which this stationary behaviour occurs. Real time location systems (RTLS) potentially offer the opportunity to gather this much needed information, but they have not been extensively trialled in office workplaces, nor rigorously compared against more familiar devices such as accelerometers.

Modelling and Phenotypic Screening of NAP-6 and 10-Cl-BBQ, AhR Ligands Displaying Selective Breast Cancer Cytotoxicity in Vitro.

To exploit the interaction of the aryl hydrocarbon receptor (AhR) pathway in developing breast-cancer-specific cytotoxic compounds, we examined the breast cancer selectivity and the docking pose of the AhR ligands (Z)-2-(2-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (NAP-6; 5) and 10-chloro-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one (10-Cl-BBQ; 6). While the breast cancer selectivity of 5 in vitro is known, we discuss the SAR around this lead and, by using phenotypic cell-line screening and the MTT assay, show for the first time that 6 also presents with breast cancer selectivity, notably in the triple-negative (TN) receptor breast cancer cell line MDA-MB-468, the ER+ breast cancer cell lines T47D, ZR-75-1 and the HER2+ breast cancer cell line SKBR3 (GI values of 0.098, 0.