Publications by authors named "Brett Masters"
Article Synopsis
- Novel proteomics platforms like SOMAscan are becoming popular for efficiently quantifying proteins, but their comparison with traditional immunoassays is not well-studied.
- A study of 63 proteins in COPD patients shows that the correlation between SOMAscan and immunoassay results varies widely, with a median correlation coefficient of about 0.5.
- The findings emphasize the need for caution when comparing data across different proteomics methods and highlight the importance of integrating various data sources for better analysis.
Background: Chronic obstructive pulmonary disease (COPD) is associated with an inflammatory response that becomes more pronounced in acute exacerbations. Considerable attention has recently focused on the value of several inflammatory mediators in predicting worsening of COPD-related symptoms. Whereas respiratory muscle dysfunction is also widely present in this population, little is known about how systemic inflammation relates to inspiratory muscle dysfunction in COPD.
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