Publications by authors named "Brett D Friedler"
Article Synopsis
- - Sirtuins are proteins that play roles in aging, metabolism, and regulating cell processes, with Sirt3 being specific to mitochondrial functions during post-stroke recovery, yet its role was not well-studied.
- - Research using Sirt3 knockout mice showed these mice experienced significant neuroprotection after stroke, likely due to an increase in Sirt1 levels that counterbalance the absence of Sirt3, affecting LKB1 activity.
- - The study highlights the need for both pharmacological and genetic approaches in pre-clinical stroke research, as inhibiting Sirt3 did not yield expected neuroprotective benefits despite some deacetylation activity being evident.
Social isolation (SI) increases stroke-related mortality and morbidity in clinical populations. The detrimental effects of SI have been successfully modeled in the laboratory using young animals. Mechanistically, the negative effects of SI in young animals are primarily mediated by an enhanced inflammatory response to injury and a reduction in neurotrophic factors.
View Article and Find Full Text PDFSocial isolation (SI) has been linked epidemiologically to high rates of morbidity and mortality following stroke. In contrast, strong social support enhances recovery and lowers stroke recurrence. However, the mechanism by which social support influences stroke recovery has not been adequately explored.
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