Health economic analysis of polygenic risk score use in primary prevention of coronary artery disease - A system dynamics model.

Background: Primary prevention programs utilising traditional risk scores fail to identify all individuals who suffer acute cardiovascular events. We aimed to model the impact and cost effectiveness of incorporating a Polygenic risk scores (PRS) into the cardiovascular disease CVD primary prevention program in Australia, using a whole-of-system model.

Methods: System dynamics models, encompassing acute and chronic CVD care in the Australian healthcare setting, assessing the cost-effectiveness of incorporating a CAD-PRS in the primary prevention setting.

Multi-year antimicrobial-resistance trends in urine Escherichia coli isolates from both community-based and hospital-based laboratories of an Australian local health district.

Objectives: Efforts to monitor and combat antimicrobial resistance (AMR) are typically focused on the hospital-based laboratory setting. The aim of this study was to longitudinally examine and compare trends in AMR among urine Escherichia coli isolates from a private community-based laboratory and a public hospital-based laboratory in an Australian local health district.

Methods: A total of 108 262 urine E.

Key predictors and burden of meticillin-resistant Staphylococcus aureus infection in comparison with meticillin-susceptible S. aureus infection in an Australian hospital setting.

Background: Staphylococcus aureus is associated with significant mortality and increased burden on the healthcare system. Relatively few reliable estimates are available regarding the impact of meticillin-resistant S. aureus (MRSA) infection compared with meticillin-susceptible S.

Identifying Rewards Over Difficulties Buffers the Impact of Time in COVID-19 Lockdown for Parents in Australia.

Objective: Physical isolation measures, known as lockdown or shelter-in-place, experienced during coronavirus disease 2019 (COVID-19) have the potential to cause psychological distress. This study was conducted to examine parents' perceived stress and whether reports of rewards and challenges during lockdown impact stress.

Methods: Data were collected using a cross-sectional online survey in New South Wales, Australia, across the 4-week lockdown.

Climatic and ecological determinants of leaf lifespan in polar forests of the high CO Cretaceous 'greenhouse' world.

Polar forests once extended across the high-latitude landmasses during ice-free 'greenhouse' intervals in Earth history. In the Cretaceous 'greenhouse' world, Arctic conifer forests were considered predominantly deciduous, while those on Antarctica contained a significantly greater proportion of evergreens. To investigate the causes of this distinctive biogeographical pattern, we developed a coupled model of conifer growth, soil biogeochemistry and forest dynamics.

The impact of diffusion and stirring on the dynamics of interacting populations.

We investigate the combined effects of diffusion and stirring on the dynamics of interacting populations which have spatial structure. Specifically we consider the marine phytoplankton and zooplankton populations, and model them as an excitable medium. The results are applicable to other biological and chemical systems.

Ethnicity, socio-economic status, overweight and underweight in East London adolescents.

Background: The developed world is experiencing an 'epidemic' of childhood obesity but little is known about the prevalence of obesity, or underweight, amongst adolescents from minority ethnic groups in the UK. An understanding of the prevalence of obesity and overweight in these populations is important since some ethnic groups may be particularly vulnerable to the adverse health effects associated with obesity.

Study Objectives: To examine levels of extreme obesity, obesity, overweight and underweight amongst a representative sample of adolescents from different ethnic groups in East London and to explore the association between socio-economic status and body mass index (BMI).

Who makes good use of memory aids? Results of a survey of people with acquired brain injury.

Wilson and Watson (1996) identified several factors that were associated with use of memory aids and strategies in a group of people with acquired brain injury. The present study tested these findings, with the aim of identifying the variables that best predict effective use of memory aids after brain injury. One-hundred and one people with memory problems arising from brain injury and their carers were interviewed to identify the aids/strategies used to compensate for memory impairment, and the efficacy of their use.

Qualitative responses of children to environmental noise.

Results from recent quantitative research consistently demonstrate that children are a high risk group, vulnerable to the adverse effects of noise exposure, especially effects on cognitive performance, motivation and annoyance. The aims of the two qualitative studies reported in this paper are to explore children's a) perception of noise exposure; b) perceived risk of and attitudes towards noise pollution; c) coping strategies; and d) the annoyance response. The Millennium Conference Study involved focus group interviews with an international sample (n=36) unselected by exposure.

The West London Schools Study: the effects of chronic aircraft noise exposure on child health.

Background: Previous field studies have indicated that children's cognitive performance is impaired by chronic aircraft noise exposure. However, these studies have not been of sufficient size to account adequately for the role of confounding factors. The objective of this study was to test whether cognitive impairments and stress responses (catecholamines, cortisol and perceived stress) are attributable to aircraft noise exposure after adjustment for school and individual level confounding factors and to examine whether children exposed to high levels of social disadvantage are at greater risk of noise effects.