Surgery in papillary thyroid carcinoma: a review of 730 patients.

Between 1956 and 1978, 1143 patients with thyroid cancer, nearly half of all patients with thyroid carcinomas in Norway in this period, were seen in our hospital. Of 730 papillary cancer patients, 447 were operated with total thyroidectomy (TT), 179 with hemi-thyroidectomy (HT), while 104 patients had minor thyroid resections (RT). Survival and recurrence rates were similar in the TT- and HT-groups.

Postoperative radiotherapy in breast cancer--long-term results from the Oslo study.

The long-term results of a randomized clinical trial evaluating the effect of postoperative radiotherapy as an adjuvant to radical mastectomy are presented. There were 1115 patients including 27 protocol deviants. The follow-up time is 11-20 years.

Prognostic factors in liposarcoma.

In a series of 99 liposarcomas, the prognostic impact of the various diagnostic and therapeutic factors was analyzed. The analysis indicated that the tumor size, histologic subtype, and x-ray density are important prognostic factors. The prognosis is also influenced by operability and treatment modalities employed.

Incidence and control of occult neck node metastases from squamous cell carcinoma of the anterior two-thirds of the tongue.

Cervical lymph node metastases developed in 45% of patients with T1N0 squamous cell carcinomas of the oral tongue in spite of local control of the primary lesions in 79%. The control rate for the neck of those who converted from a negative to a positive neck (N0-N+) was 33%. Neck node metastases developed in 49% of patients with T2N0 tumors.

Squamous-cell carcinoma of the tongue: preoperative interstitial radium and external irradiation. Part II: Survival.

The authors evaluated 300 cases of squamous-cell carcinoma of the anterior two thirds of the tongue treated from 1958 through 1972. Effects of treatment on absolute and relative survival were determined by the log rank method. Selection was non-random, based on the extent of the primary tumor, age, and general condition.

Squamous-cell carcinoma of the tongue: preoperative interstitial radium and external irradiation. Part I: Local and regional control.

Results of therapy in 300 patients with squamous-cell carcinoma of the anterior two thirds of the tongue are presented in terms of control of the primary tumor (local) and metastases to the lymph nodes of the neck (regional). Correlation between clinical stage and control was good, with the best results being obtained in stage T1N0 (84% control of tongue, 69% control of neck) and the poorest results in TX N2N3 (9% and 11%, respectively). Different methods of treatment were analyzed separately for various stages of disease and compared with results from other institutions.

Anomalous papillary carcinoma of the thyroid.

Most papillary carcinomas of the thyroid run a surprisingly indolent clinical course, and even widespread lymph node metastases in the neck are not a bad prognostic omen. A small group behaves in a far more aggressive fashion and kills through local invasion of adjacent structures or blood borne metastases. This paper deals with a papillary carcinoma which does not fit into any of these groups.

Early detection of breast cancer by leukocyte adherence inhibition assay.

The hematocytometer leukocyte adherence inhibition technique was used to study cell-mediated immune activity against breast carcinoma. In a group of 83 patients with untreated breast cancer in stage I, 74% showed a positive response, among 47 patients in stage II, 64% responded, while only 51% of the 37 patients in stages III and IV responded. Of 86 control persons, only two women showed a positive response.

Leukocyte adherence inhibition assay in human pulmonary neoplasia.

The hemocytometer leukocyte adherence inhibition technique was used to study cell-mediated immuno-activity of patients with lung cancer. KCl extracts (3.5 M) from the lung cancer cell line Calu-1 and the breast cancer cell line MCF-7 were used as antigens.

Carcinoma of the tongue in Norway and Wisconsin. II. Influence of site and clinical stage on local control of the tumor.

The local control rates in patients with squamous cell carcinoma of the tongue, treated between 1958 and 1972, were determined by retrospective analysis of the records of 339 patients at the Norwegian Radium Hospital and of 164 patients at the University of Wisconsin Hospitals. The correlation between the clinical stage and the local control rate was good in Norway, less striking in Wisconsin. As the tumor grew in size it generally became increasingly difficult to control.

Carcinoma of the tongue in Norway and Wisconsin. I. Incidence and prognosis related to sex and age.

The records of 503 patients with carcinoma of the tongue diagnosed between 1958 and 1972 were reviewed. The preponderance of tongue carcinoma among men was confirmed both in The Norwegian Radium Hospital (NRH) and the University of Wisconsin Hospitals (UW), but it was relatively more frequent among women in NRH and in UW than in southern Europe. More women had on presentation less advanced tumors at NRH than at UW.

Familial occurrence of papillary thyroid carcinoma.

We report two kindreds from northern Norway with 7 and 4 cases of papillary thyroid carcinoma in otherwise healthy, nonirradiated subjects. While histologic features were comparable the patient's age at the time of diagnosis was lower and lymph node metastases were more frequent in familial than in nonfamilial cases of papillary thyroid carcinoma from the same region. We conclude that genetic factors can predispose the patient for development of papillary thyroid carcinoma.

Stage I melanoma of the limbs. Immediate versus delayed node dissection.

553 patients with stage I malignant melanoma of the limbs entered a prospective randomized clinical trial carried out by the W.H.O.

Cellular antitumor immune response in women with risk factors for breast cancer.

The leukocyte adherence inhibition technique was used to study cell-mediated immunoactivity to breast adenocarcinoma. In a group of 74 patients with untreated breast cancer in Stages I and II, 69% showed a positive response, while 48% of the 25 patients in Stages III and IV had reactive leukocytes. Among 43 control persons, only 2 women showed positive responses.

Inefficacy of immediate node dissection in stage 1 melanoma of the limbs.

From September, 1967, to January, 1974, a clinical trial was carried out by the WHO Melanoma Group to evaluate the efficacy of elective lymph-node dissection in the treatment of malignant melanoma of the extremities with clinically uninvolved regional lymph nodes. Treatment was prospectively randomized: 267 patients to excision of primary melanoma and immediate regional-lymph-node dissection and 286 to excision of primary melanoma and regional-lymph-node dissection at the time of appearance of metastases. The statistical analysis showed no difference in survival between the two groups of patients, regardless of how the data were analyzed (according to sex, site of origin, maximum diameter of primary tumor or Clark's level or Breslow's thickness).

HLA antigens in malignant melanoma.

HLA-A, -B, -C and -D typing was performed on 54 Norwegian patients with microscopically verified malignant melanoma. A slight, but non-significant increase in the frequency of HLA-B27 and LD 108 was demonstrated among the patients compared with healthy Norwegian controls.

Human submandibular gland tissue in culture 2. Nickel affinity to secretory proteins.

In view of the exposure to nickel through the oral cavity the relation between this metal (as 63NiCl2) and salivary macromolecules was studied by tissue culture, isoelectric focusing and equilibrium dialysis. During cultivation of human submandibular gland tissue, small amounts of nickel were incorporated into macromolecules with an isoelectric point of about 4.4 and approximately 7.

Human submandibular gland tissue in culture I. Sulphate incorporation and tissue culture technique.

In vitro cultivation of human submandibular gland tissue resulted in release of salivary proteins corresponding to about 50% of the total content after 48 hours. The admixture of plasma proteins as judged by single radial immunodiffusion took place early in the incubation period, and could be reduced by discarding the first washing medium. Hydroxyproline measurements in the medium indicated that the autolysis increased significantly after two days of incubation.

HLA antigens in malignant melanoma.

HLA-A, -B, -C, and -D typing was performed on 54 Norwegian patients with microscopically verified malignant melanoma. A slight, but nonsignificant, increase in the frequency of HLA-B27 and LD 108 was demonstrated among the patients, compared with healthy Norwegian controls.