Publications by authors named "Brennen McKenzie"

Article Synopsis
  • The study aimed to analyze the effects of a high-fat diet on body composition, insulin sensitivity, blood lipids, and metabolic changes in aging.
  • 24 male Beagle dogs were divided into two groups, one continuing their regular diet and the other switched to a high-fat diet for 17 weeks.
  • Results indicated that the high-fat diet led to weight gain, increased fat mass, insulin resistance, and higher serum lipid levels, mirroring metabolic dysfunction associated with aging.
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General practice veterinarians (GPs) are often faced with the question of which services they should provide themselves and which are more appropriately the province of board-certified specialists. The growing availability of specialty care, the expectations of many pet owners for advanced care resembling that which they receive, the expanding availability of new and more technologically sophisticated interventions, and many less easily defined shifts in the economic and cultural context of veterinary medicine all add to the pressure to limit services in general practice and refer more patients to specialists. However, the criteria for making decisions about referral are often ill-defined and controversial.

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Objective: The aim of this study is to evaluate age, sex, body weight, breed, neuter status, and age at neutering as risk factors for diagnosis of osteoarthritis in companion dogs.

Animals: Dogs seen as patients at Banfield Pet Hospital in the United States from 1998 to 2019 with a date of death in 2019. The final cohort consisted of 131,140 dogs.

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Article Synopsis
  • Developing reliable tools to assess factors like frailty and health-related quality of life (HRQL) is vital for understanding aging in dogs and can also inform research on human aging.
  • In a study involving 451 adult dogs, researchers validated the Canine Frailty Index (CFI) and VetMetrica HRQL tools, showing that older dogs (7 years and up) exhibit higher frailty and lower HRQL compared to younger dogs (2-6 years).
  • The study found that body size didn't significantly affect frailty or HRQL scores, but larger, older dogs had a quicker decline in owner-reported activity and comfort levels, highlighting the need for these tools in advancing dog healthspan research and gerotherapeutics for
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Aging is the leading cause of disability, disease, and death in adult dogs. One major consequence of aging is diminishing physical function. For normal functioning, basic elements such as strength, balance, and energy must be present.

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Biological aging is the single most important risk factor for disease, disability, and ultimately death in geriatric dogs. The effects of aging in companion dogs also impose significant financial and psychological burdens on their human caregivers. The underlying physiologic processes of canine aging may be occult, or early signs of aging may be ignored because of the misconception that biological aging is natural and therefore inevitable.

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Aging is the single most important cause of disease, disability, and death in companion animal species. Contrary to the common view of aging as mysterious and inevitable, it is more usefully understood as a set of complex but comprehensible and modifiable biological processes that are highly conserved across species. The purpose of this Currents in One Health manuscript is to describe key mechanisms of aging at the cellular and molecular level and the manifestations of these in the tissues of the musculoskeletal system, adipose, and the brain.

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Aging is the single most important cause of disease, disability, and death in adult dogs. Contrary to the common view of aging as a mysterious and inevitable natural event, it is more usefully understood as a set of complex but comprehensible biological processes that are highly conserved across species. Although the phenotypic expression of these processes is variable, there are consistent patterns both within and between species.

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