Varicella zoster meningitis complicating combined anti-tumor necrosis factor and corticosteroid therapy in Crohn's disease.

Opportunistic viral infections are a well-recognized complication of anti-tumor necrosis factor (TNF) therapy for inflammatory bowel disease (IBD). Cases of severe or atypical varicella zoster virus infection, both primary and latent reactivation, have been described in association with immunosuppression of Crohn's disease (CD) patients. However, central nervous system varicella zoster virus infections have been rarely described, and there are no previous reports of varicella zoster virus meningitis associated with anti-TNF therapy among the CD population.

A prospective audit of patient experiences in colonoscopy using the Global Rating Scale: a cohort of 1,187 patients.

Background: The Global Rating Scale (GRS) comprehensively evaluates the quality of an endoscopy department, providing a patient-centred framework for service improvement.

Objective: To assess patient experiences during colonoscopy and identify areas that need service improvement using the GRS.

Methods: Consecutive outpatients undergoing colonoscopy were asked to complete a pre- and postprocedure questionnaire.