Publications by authors named "Brendon Z J Yeo"
Article Synopsis
- Tyrosine kinase inhibitors (TKIs) are the main treatment for non-small cell lung cancer (NSCLC) with EGFR mutations, but resistance to these drugs often develops due to new mutations and they can cause severe side effects.
- Researchers are exploring customized antisense oligonucleotides (ASOs) to specifically target these mutations, using extracellular vesicles to deliver them directly to cancer cells.
- Preliminary results show that ASOs can effectively reduce tumor growth in models of NSCLC and may work better than TKIs, offering a promising new treatment approach tailored to individual genetic profiles.
The COVID-19 pandemic has resulted in a large number of fatalities and, at present, lacks a readily available curative treatment for patients. Here, we demonstrate that unmodified red blood cell-derived extracellular vesicles (RBCEVs) can inhibit SARS-CoV-2 infection in a phosphatidylserine (PS) dependent manner. Using T cell immunoglobulin mucin domain-1 (TIM-1) as an example, we demonstrate that PS receptors on cells can significantly increase the adsorption and infection of authentic and pseudotyped SARS-CoV-2 viruses.
View Article and Find Full Text PDFNanoparticles (NPs) hold great potential as therapeutics, particularly in the realm of drug delivery. They are effective at functional cargo delivery and offer a great degree of amenability that can be used to offset toxic side effects or to target drugs to specific regions in the body. However, there are many challenges associated with the development of NP-based drug formulations that hamper their successful clinical translation.
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