Publications by authors named "Brendan Wood"
Perioperative Management of Direct Oral Anticoagulants in Cardiac Surgery: Practice Recommendations Based on Current Evidence.
J Cardiothorac Vasc Anesth
November 2022
An increasing number of patients on systemic oral anticoagulants present for cardiac surgery, and cardiac anesthesiologists should be well-informed on their management in the perioperative period. Direct oral anticoagulants (DOACs), including factor Xa inhibitors and direct thrombin inhibitors, are an attractive alternative to warfarin due to fewer dietary and drug interactions, less frequent monitoring requirements, and an improved patient adherence. Since the approval of DOACs by the Food and Drug Administration in 2010, the number of patients on these medications only has increased.
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- The study aimed to determine if modafinil could enhance recovery after general anesthesia in patients with obstructive sleep apnea by assessing outcomes like extubation time and PACU stay.
- The pilot study involved 102 patients who were randomly assigned to receive either modafinil or a placebo, but it was terminated early due to lack of significant results.
- Ultimately, the findings indicated no difference in recovery metrics between the modafinil and placebo groups, suggesting that modafinil may not be beneficial for this purpose in patients with OSA.
The Anticoagulated trauma patient in the age of the direct oral anticoagulants: a Canadian perspective.
Scand J Trauma Resusc Emerg Med
August 2017
Background: The anticoagulated trauma patient presents a particular challenge to the critical care physician. Our understanding of these patients is defined and extrapolated by experience with patients on warfarin pre-injury. Today, many patients who would have been on warfarin are now prescribed the Direct Oral Anticoagulants (DOACs) a class of anticoagulants with entirely different mechanisms of action, effects on routine coagulation assays and approach to reversal.
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- The giraffe's tall stature and unique cardiovascular adaptations are not fully understood, but studying its closest relative, the okapi, helps identify genetic differences.
- Scientists sequenced the genomes of both animals and found specific genes (like those in the HOX, NOTCH, and FGF pathways) that likely contribute to the giraffe's distinct features.
- Additionally, notable evolutionary changes were found in DNA repair and centrosome functions, highlighting how giraffes have adapted to their unique diets and tall structure.
Objectives: The study examines the meaning of good-quality social care for people with Parkinson's disease and their carers. It identifies, from their perspective, the impact of good-quality social care on health and well-being.
Design: Qualitative case study methodology, interview and framework analysis techniques were used.
Objectives: The favorable CC genotype at rs12979860 upstream of the interleukin (IL)-28B gene is correlated with a greater post-treatment sustained virologic response rate in chronic hepatitis C infected patients. We report on our validation of a clinical genotyping assay for rs12979860 polymorphisms in the IL28B locus.
Design And Methods: The rs12979860 genotype was determined using a TaqMan® Real-Time PCR allelic discrimination assay with primers and probes specific for the C and T alleles on the Applied Biosystems 7500 Fast Real-Time PCR System.