Publications by authors named "Brendan Mackay"

Background: Tendon repairs often result in adhesion formation which can cause persisting functional deficits. Close proximity of healing tissues increases friction during tendon excursion, often leading to tendon tethering postoperatively. Despite continued improvements in techniques for tendon repairs, there is currently no consensus on the most effective modality to reduce adhesion formation.

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Purpose: In the adult literature, allograft reconstruction of gapped peripheral nerve injuries has gained popularity over autologous nerve grafting. Allografts have demonstrated similar recovery while eliminating donor site morbidity. There is no well-defined incidence or treatment of such injuries in children.

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Background: Peripheral nerve injuries (PNIs) are associated with significant physical and psychological challenges, impacting both functional recovery and quality of life. Despite the physical focus of traditional treatments, psychological factors play a crucial role in the outcomes of PNI repair and recovery.

Objectives: This systematic review aims to evaluate the impact of psychological and social factors on the repair and recovery of peripheral nerve injuries.

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Article Synopsis
  • The musculoskeletal system is prone to joint pain from conditions like rheumatoid arthritis and osteoarthritis, prompting the exploration of peptides as a new treatment option that is safe and minimally invasive.
  • This study reviews existing oral and intra-articular peptide therapies, focusing on their effectiveness for soft tissue regeneration and comparing their delivery routes.
  • The review found that both oral and intra-articular peptides can aid in soft tissue repair, but each has its own challenges of bioavailability, and more research is needed to establish their efficacy before they are widely adopted as an alternative to surgery.
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  • Corticosteroids, known for their anti-inflammatory properties, may be helpful in treating peripheral nerve injuries, despite limited current use.
  • A systematic review of studies revealed that corticosteroids can provide pain relief and support nerve regeneration in conditions like cubital tunnel syndrome and chronic inflammatory demyelinating polyradiculoneuropathy.
  • While promising, the research suggests more clinical trials are needed to fully understand the potential benefits and safety of corticosteroid treatment for peripheral nerve pathologies.
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Hypothesis/background: Patient-specific implants have become an increasingly researched area to improve surgical outcomes. Patient-specific implants have been suggested to provide advantages for better implant alignment and thus improve surgical outcomes. One such area for application is in the use of intramedullary nails for humeral fracture stabilization.

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Article Synopsis
  • The case report discusses the successful application of the Titanium Elastic Nail System (TENS) in treating a mid-shaft fracture of the radius and ulna in a patient with a complex medical history.
  • The report highlights how TENS provided a minimally invasive treatment solution that led to complete fracture healing.
  • This case demonstrates the effectiveness of TENS in managing challenging orthopedic conditions, particularly when limited literature is available on similar cases.
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In this report, we detail a 69-year-old female who sustained a comminuted intra-articular left distal radius fracture that failed to heal with bridge plate fixation. Given the patient's poor subchondral bone stock and refusal of bone autograft, we designed a construct using a dorsal spanning plate and an intramedullary fragment-specific plate as a volarly placed strut in combination with viable bone allograft and cancellous bone chips to treat this nonunion. This case demonstrates an option for distal radius non-union treatment and highlights the importance of ingenuity that orthopedic surgeons should demonstrate when trying to accommodate patients' wishes.

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Dorsal spanning plates are frequently utilized to manage comminuted intra-articular distal radius fractures, but there is little literature on combining them with augmented fixation in complex cases. We present a 43-year-old man who fell 5 ft onto his outstretched right hand. On examination, there was gross swelling and tenderness of the right wrist with no neurovascular deficit.

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Background: The opioid crisis has become a present concern in the medical field. In an effort to address these complications, antineuropathic pain medications have been considered as alternatives to prescribed opioids.

Objective: This review focuses on the analgesic effects of neuromodulators, such as gabapentin, duloxetine, and pregabalin, that provide room for less dependence on narcotic analgesics following orthopedic surgery.

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Traditionally, full-thickness wounds with exposed structures are treated with flap coverage or dermal regenerative templates. Most dermal regenerative templates are biologic in origin, but recently synthetic options have become available. One such product is a synthetic hybrid-scale fiber matrix (SHSFM).

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Background: Orthopaedic procedures require postoperative follow-up to maximize recovery. Missed appointments and noncompliance can result in complications and increased healthcare costs. This study investigates the relationship between patient postoperative visit attendance and the distance traveled to receive care.

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Purpose: The purpose of this study was to determine whether a relationship exists between body mass index (BMI), specifically obesity, and surgical outcomes for open carpal tunnel release. Obesity is correlated with increased incidence of carpal tunnel syndrome; however, the effect of obesity on after release recovery has not been examined.

Methods: This study used a retrospective review of patient charts (n = 142).

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Introduction: This study examines the relationship between smoking status and surgical outcomes in open carpal tunnel release. Smoking status has previously been correlated with orthopedic surgical complications unless smoking cessation occurs at least 4 weeks prior to surgery; however, the effect of smoking on open carpal tunnel release has not been specifically examined.

Methods: This study is a retrospective review of patient charts over the last 5 years (n = 131).

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Metacarpal fractures are common and may require operative treatment; however, there is no gold standard fixation technique. K-wires are used for simplicity and flexibility but require immobilization and can lead to complications. Dorsal plating provides greater stability than K-wires but is subject to its own limitations.

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Background: Studies addressing the utility of hemoglobin A1c (HbA1c) levels in predicting surgical complications have reported mixed results. In practice, many surgeons use HbA1c cutoffs to determine a patient's eligibility for elective surgery. The literature is especially limited in evaluating HbA1c as a risk factor in elective hand and upper extremity surgery.

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Porcine-derived UBM, a type of acellular ECM, has demonstrated clinical utility for tissue repair and regeneration across various body systems. UBM acts as a full-thickness, exogenic skin substitute and scaffolding for soft tissue reconstruction while mimicking the function and properties of human ECM. This review presents an overview of the current literature evaluating UBM's clinical and preclinical utility across a broad range of applications.

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Traumatic brain injuries have the potential to cause the development of long-term complications. We aim to show that the use of flexor tenotomies in the treatment of flexion contractures following traumatic brain injury is a viable solution.

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Chronic distal radioulnar joint (DRUJ) instability is a complex clinical condition that is difficult to treat. Currently, there is no gold standard treatment. We present a novel technique using Arthrex Mini Tightrope for DRUJ stabilization.

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 Peripheral nerve function is often difficult to assess given the highly variable presentation and subjective patient experience of nerve injury. If nerve assessment is incomplete or inaccurate, inappropriate diagnosis and subsequent treatment may result in permanent dysfunction.  As our understanding of nerve repair and generation evolves, so have tools for evaluating peripheral nerve function, recovery, and nerve-related impact on the quality of life.

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Objective Injuries resulting from trauma or tumor resection may cause length alterations in the bones of the upper extremities (UE) requiring reconstruction. Direct contralateral bone is often used to determine the appropriate length for reconstruction but fails to account for potential asymmetry. Given the paucity of data assessing asymmetry in living populations and the need for accurate length approximation, we developed a study evaluating UE long bone asymmetry using radiographic imaging in living subjects.

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Article Synopsis
  • - Amputations have changed little over time, typically involving ligation of blood vessels, shortening of bones, and cutting of nerves, which can lead to significant pain issues for patients.
  • - Targeted muscle reinnervation is a newer surgical technique aimed at enhancing function in prosthetic users and is increasingly used to manage neuropathic pain.
  • - The article serves as a consensus statement from experienced surgeons to provide guidelines and a framework for successful implementation of targeted muscle reinnervation among extremity surgeons.
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Unlabelled: Revision nerve decompression remains a challenge for surgeons. Avive Soft Tissue Membrane is processed human umbilical cord membrane that may reduce inflammation and scarring, thereby improving tissue gliding. Although synthetic conduits have been reported in revision nerve decompression, the use of Avive has not.

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  • CMC fracture-dislocations are rare hand injuries with limited treatment options, including K-wires, mini-screws, and plates, but there's no standardized method due to diverse injury patterns and complications.* -
  • The INnate™ threaded intramedullary nail is a newer treatment that has been effective for metacarpal fractures, offering quicker recovery and stability without compressing the fracture.* -
  • A study evaluated the INnate™ nail on nine patients with CMC fracture-dislocations, showing promising results with painless outcomes, good range of motion, and 84% return to normal activities, with few complications.*
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The aim of the study was to determine the efficacy of carbapenem-only combination treatments derived from four approved drugs (meropenem, doripenem, ertapenem and imipenem) against a MDR strain of in a larvae infection model. larvae were infected with NCTC 13437 (carrying the VIM 10 carbapenamase) and the efficacy of the six possible dual, four triple, and one quadruple carbapenem combination(s) were compared to their constituent monotherapies. Four of these combinations showed significantly enhanced survival compared to monotherapies and reduced the bacterial burden inside infected larvae but without complete elimination.

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