Publications by authors named "Brendan J Lee"
Article Synopsis
- Researchers have created a new radiopharmaceutical, PBR316, designed to target the translocator protein 18 kDa (TSPO) for studying neuroinflammation, degeneration, and cancer using PET imaging.
- PBR316 boasts high binding affinity for TSPO, improved specificity, and reduced influence from genetic variations in humans related to TSPO binding, making it a promising tool for imaging studies.
- Biodistribution studies in rats and mouse models show that PBR316 effectively accumulates in TSPO-expressing tissues, including the brain and tumors, indicating its potential for further biological and clinical research.
Cancer Discov
October 2020
Article Synopsis
- * Hydroxychloroquine combined with other drugs increased mortality compared to alternative treatments or no treatment, while remdesivir showed a trend towards reduced mortality that wasn't statistically significant.
- * Treatment receipt was influenced by factors like baseline COVID-19 severity and revealed disparities, such as Black patients being less likely to receive remdesivir than white patients, emphasizing the need for more inclusive trials.
