Topically Applied Therapies for the Treatment of Skin Disease: Past, Present, and Future.

The purpose of this review is to summarize essential biological, pharmaceutical, and clinical aspects in the field of topically applied medicines that may help scientists when trying to develop new topical medicines. After a brief history of topical drug delivery, a review of the structure and function of the skin and routes of drug absorption and their limitations is provided. The most prevalent diseases and current topical treatment approaches are then detailed, the organization of which reflects the key disease categories of autoimmune and inflammatory diseases, microbial infections, skin cancers, and genetic skin diseases.

Periodic/Aperiodic parameterization of transient oscillations (PAPTO)-Implications for healthy ageing.

Two techniques for analyzing human extracranial neurophysiological signals, namely the periodic/aperiodic parameterization of neural power spectra and the transient events framework of oscillatory activity, have recently emerged in the scientific literature. In this work, we integrate these two analysis perspectives to analyze extracranial neurophysiological signals as a series of transient rhythmic events disambiguated from the background aperiodic activity. We call this novel technique the periodic/aperiodic parametrization of transient oscillations (PAPTO).

Age-related trends in neuromagnetic transient beta burst characteristics during a sensorimotor task and rest in the Cam-CAN open-access dataset.

Non-invasive neurophysiological recordings, such as those measured by magnetoencelography (MEG), provide insight into the behaviour of neural networks and how these networks change with factors such as task performance, disease state, and age. Recently, there has been a trend in describing neurophysiological recordings as a series of transient bursts of neural activity rather than averaged sustained oscillations as burst characteristics may be more directly correlated with the neurological generators of brain activity. In this work, we investigate how beta burst characteristics change with age in a large open access dataset.

Highly sensitive protein detection via covalently linked aptamer to MoS and exonuclease-assisted amplification strategy.

Molybdenum disulfide (MoS) has shown highly attractive superiority as a platform for sensing. However, DNA physisorption on the surface of MoS was susceptible to nonspecific probe displacement and false-positive signals. To solve these problems, we have developed a novel MoS-aptamer nanosheet biosensor for detecting thrombin using a covalently linked aptamer to the MoS nanosheet.

Protein determination using graphene oxide-aptamer modified gold nanoparticles in combination with Tween 80.

Recently, graphene oxide (GO) has shown superiority for disease detection arising from its unique physical and chemical properties. However, proteins adsorbed on the surface of GO prevent sensitivity improvement in fluorescence-based detection methods. In this paper, a label-free method based on aptamer modified gold nanoparticles (GNPs) combined with Tween 80 was shown to solve this problem using the detection of thrombin as an example.