Evaluation of mouthrinse and dentifrice regimens in an in situ erosion remineralisation model.

Objectives: To compare the effectiveness of dentifrice/mouthrinse regimens in a clinical in situ erosion remineralisation model.

Methods: Thirty-six subjects completed a randomised single-blind cross-over trial of five treatment regimens. R1: Dentifrice A [1450 ppm fluoride as the sodium salt (NaF), 50000 ppm potassium nitrate (KNO(3))] plus 450 ppm fluoride (NaF) rinse; R2: Dentifrice A plus sterile water rinse; R3: Dentifrice B (fluoride-free Dentifrice A) plus sterile water rinse; R4: Dentifrice B plus 450 ppm fluoride (NaF) rinse; R5: Dentifrice C (1000 ppm fluorine as sodium monofluorophosphate, 450 ppm fluoride as NaF) plus sterile water rinse.

A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentin hypersensitivity.

Objective: The objective of this clinical study was to evaluate and compare the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride (from sodium fluoride) in a silica base (test dentifrice) to a control dentifrice containing 1450 ppm fluoride (from sodium fluoride) in a silica base, to reduce dentin hypersensitivity immediately after a single dab-on self-application, and after subsequent twice-daily brushing for three days.

Methods: This was a randomized, examiner-blind, two-arm parallel group, three-day clinical study with seventy-nine subjects, stratified based on baseline tooth sensitivity. Tooth sensitivity was determined through subject responses to both evaporative (Schiff and Visual Analogue Scale [VAS]) and tactile stimuli (Yeaple probe), prior to and immediately after subjects self-applied a single pea-sized amount of either the test or control dentifrice to qualifying sensitive teeth, massaging the toothpaste onto the sensitive area for one minute.

A comparative clinical study evaluating stain removal efficacy of a new sensitivity whitening dentifrice compared to commercially available whitening dentifrices.

Objective: To assess the extrinsic stain removal efficacy of a new sensitivity dentifrice containing sodium tripolyphosphate (STP) to marketed whitening toothpastes after six weeks of product use.

Methods: This was a single-center, double-blind, stratified, six-week clinical study comparing the reduction in stain area and intensity of Sensodyne Extra Whitening to Crest Maximum Strength Sensitivity Protection Whitening plus Scope and Colgate Tartar Control Plus Whitening Mint dentifrice, as measured by MacPherson's Modification of the Lobene Stain Index (MMLSI) in a forced stain model.

Results: Two-hundred and ninety-five subjects completed the study.

Safety evaluation of a novel whitening gel, containing 6% hydrogen peroxide and a commercially available whitening gel containing 18% carbamide peroxide in an exaggerated use clinical study.

Objectives: The aim of this study was to compare the effect on oral soft tissue of a self-applied tooth whitening gel containing 6% hydrogen peroxide (Xtra White) with a marketed paint-on whitening gel containing 18% carbamide peroxide (Colgate Simply White) after 2-weeks of using products four times daily.

Methods: A 2-week, examiner-blind, stratified, parallel design clinical trial was conducted. Twenty subjects were divided into two groups, balanced according to age and gender.

Clinical evaluation of a novel whitening gel, containing 6% hydrogen peroxide and a standard fluoride toothpaste.

Objectives: The aim of this study was to determine the effect on tooth colour (after 1 and 2 weeks use) of a self-applied tooth-whitening gel containing 6% hydrogen peroxide using a novel applicator, compared to a standard fluoride toothpaste.

Methods: A 2-week, examiner-blind, stratified, parallel design clinical trial was conducted. Efficacy was measured by comparing the Vita shade scores recorded at baseline and after 1 and 2 weeks of product application.

Evaluation of a whitening gel designed to accelerate whitening.

A clinical trial was conducted with 25 subjects to evaluate the effects and safety of Zoom! Take-Home whitening gel, a 6% hydrogen peroxide gel for vital tooth bleaching. Tooth bleaching was accomplished using a tray system overnight for 6 nights. Over the 6 nights, a significant change (from darker to lighter) was seen in tooth shades as demonstrated by 3 assessment methods: VITA Shade Value Oriented Guide, Trubyte Bioform Color Ordered Shade Guide scoring system, and the Chroma Meter CR-321 assessments.

Clinical study to compare two in-office (chairside) whitening systems.

The objective of this clinical study was to compare the whitening/bleaching efficacy of two marketed in-office whitening systems: Discus Dental Zoom! Chairside System (25% hydrogen peroxide whitening gel) and Opalescence Xtra Boost Kit (38% hydrogen peroxide whitening gel), using the Vita Shade Guide and chromameter measurements. The study was an examiner-blind, parallel group, randomized and controlled clinical trial conducted in a dental setting. All subjects signed a study consent form prior to admission and were given Crest Regular Toothpaste and an Oral-B 40 straight-handle toothbrush to use during the study.