Blunted inflammatory response is associated with a lower response to a weight loss dietary intervention in liver recipients.

Background & Aims: Obesity is associated with chronic low-grade inflammation, and adipose tissue inflammation is required for fatty tissue remodeling. Interestingly, immunosuppressed patients, as liver transplant recipients, often experience excessive weight gain. We investigated how liver recipients' inflammatory response affects body weight loss induced by dietary treatment.

Genetic deletion of Mas receptor in FVB/N mice impairs cardiac use of glucose and lipids.

Angiotensin-(1-7) is a biologically active product of the renin-angiotensin system cascade and exerts inhibitory effects on inflammation, vascular and cellular growth mechanisms signaling through the G protein-coupled Mas receptor. The major purpose of the present study was to investigate the use of glucose and fatty acids by cardiac tissue in Mas knockout mice models. Serum levels of glucose, lipids, and insulin were measured in Mas-deficient and wild-type FVB/N mice.

Hypometabolism as a potential risk factor for overweight and obesity in liver recipients.

Objective: The aim of the present study was to identify whether overweight liver recipients are hypometabolic.

Methods: Liver transplantation (LT) recipients (n = 20), who were 18 to 65 y of age, had a body mass index (BMI) ≥25 kg/m, and were 1 to 3 y post-transplant. They were matched with healthy controls in terms of sex, age, BMI, and body composition.