Loss-of-function mutations in prokineticin 2 () and the cognate receptor prokineticin receptor 2 () genes have been implicated in reproductive deficits characteristic of Kallmann Syndrome (KS). Knock out of gene produces the KS-like phenotype in mice resulting in impaired migration of gonadotropin releasing hormone (GnRH) neurons, olfactory bulb dysgenesis, and infertility. Beyond a developmental role, pharmacological and genetic studies have implicated PROKR2 in the control of the estrous cycle in mice.
View Article and Find Full Text PDFHolometabolous insects have been able to radiate to vast ecological niches as adults through the evolution of adult-specific structures such as wings, antennae and eyes. These structures arise from imaginal discs that show regenerative capacity when damaged. During imaginal disc regeneration, development has been shown to be delayed in the fruit fly , but how conserved the delay-inducing mechanisms are across holometabolous insects has not been assessed.
View Article and Find Full Text PDF