A Review on Host- Interactions: What We Know and Future Expectations.

Leptospirosis is a widespread zoonosis caused by pathogenic spp. It is considered a neglected infectious disease of human and veterinary concern. Our group has been investigating proteins annotated as hypothetical, predicted to be located on the leptospiral surface.

In Silico Structural and Functional Characterization of HtrA Proteins of spp.: Possible Implications in Pathogenesis.

Leptospirosis is a zoonosis caused by the pathogenic bacteria of the genus . The identification of conserved outer membrane proteins among pathogenic strains is a major research target in elucidating mechanisms of pathogenicity. Surface-exposed proteins are most probably the ones involved in the interaction of leptospires with the environment.

Adjuvanted leptospiral vaccines: Challenges and future development of new leptospirosis vaccines.

Leptospirosis is a neglected infectious disease of global importance. Vaccination is the most viable strategy for the control of leptospirosis, but in spite of efforts for the development of an effective vaccine against the disease, few advances have been made, and to date, bacterin is the only option for prevention of leptospirosis. Bacterins are formulations based on inactivated leptospires that present a series of drawbacks, such as serovar-dependence and short-term immunity.