Publications by authors named "Brell Jennifer"
Regulation of the Immune Cell Repertoire in Psoriasis Patients Upon Blockade of IL-17A or TNFα.
Dermatol Ther (Heidelb)
March 2024
Article Synopsis
- Treatment with monoclonal antibodies ixekizumab (anti-IL-17A) and adalimumab (anti-TNFα) is effective for managing chronic plaque psoriasis, but their impact on immune cell populations in the skin remains unclear.
- The study found that both treatments successfully reduced the levels of T cells, macrophages, and dendritic cells in the affected skin, aligning them more closely with healthy skin levels.
- However, neither treatment was able to correct the imbalance of dendritic cells in non-lesional skin of psoriatic patients, indicating that while the therapies help with lesions, they do not fully restore immune balance in unaffected areas.
Iron is essential for living cells. Uptake of iron-loaded transferrin by the transferrin receptor 1 (CD71, TFR) is a major but not sufficient mechanism and an alternative iron-loaded ligand for CD71 has been assumed. Here, we demonstrate that CD71 utilizes heme-albumin as cargo to transport iron into human cells.
View Article and Find Full Text PDFIron uptake via the transferrin receptor (CD71) is a pivotal mechanism for T cell proliferation. Yet, it is incompletely understood if targeting of CD71 also affects the differentiation and functional polarization of primary human T cells. In this study, we demonstrate that inhibition of iron ingestion with blocking mAbs against CD71 induces nonproliferating T cells, which release high amounts of IL-2.
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