The purpose of this study was to determine the best estimate of glomerular filtration rate (GFR) to adjust vancomycin (VAN) dosage in critically ill patients. Seventy-eight adult intensive care unit patients received a 15 mg/kg loading dose of VAN plus a 30 mg/kg/day continuous infusion. Steady-state concentration was measured 48 hours later and the dose was adjusted to obtain a target concentration ranging from 20 to 25 mg/l.
View Article and Find Full Text PDFIntroduction: The aim of this study, performed in an intensive care unit (ICU) population with a normal serum creatinine, was to estimate urinary creatinine clearance (CLCR) in a population of polytrauma patients (PT) through a comparison with a population of non trauma patients (NPT).
Methods: This was a retrospective, observational study in a medical and surgical ICU in a university hospital. A total of 284 patients were consecutively included.
Altered pharmacokinetics in burn patients may affect antibiotic plasma concentrations. Typical once-daily dosing (ODD) of 15 mg/kg amikacin (AMK) in burn patients does not always produce peak concentrations (C(max)) reaching the therapeutic objective of six to eight times the minimal inhibitory concentration (MIC). We recorded plasma concentrations following administration of 20 mg/kg AMK in burn patients and studied factors affecting pharmacokinetics.
View Article and Find Full Text PDFThe occupational therapist is vital to providing a complete assessment and thorough treatment of the population with eating disorders. Symptoms and etiology that effect the occupational therapist's reasoning are explored followed by the theoretical frameworks used and specific group intervention at the Sheppard and Enoch Pratt Hospital. Two case studies conclude the article.
View Article and Find Full Text PDF