Publications by authors named "Brechtje D M Koopmann"
Article Synopsis
- New-onset diabetes mellitus (NOD) may signal early pancreatic ductal adenocarcinoma (PDAC), prompting recommendations for glucose and HbA1c monitoring in high-risk individuals (HRIs).
- A study involving 404 HRIs undergoing routine surveillance found no significant differences in glucose or HbA1c levels between those who developed PDAC and those who did not.
- The findings indicate that monitoring glucose and HbA1c does not aid in detecting PDAC in this population, suggesting the need for larger, long-term studies to evaluate its effectiveness.
Background: As the impact of unmanaged bias (i.e. systematic source of inaccuracy) in fecal immunochemical test (FIT) analytical performance on long-term colorectal cancer (CRC) outcomes is unknown, we assessed the impact bias in FIT performance in an ongoing FIT-based CRC screening program.
View Article and Find Full Text PDFBackground & Aims: Estimates on the progression of precursor lesions to pancreatic cancer (PC) are scarce. We used microsimulation modeling to gain insight into the natural disease course of PC and its precursors. This information is pivotal to explore the efficacy of PC screening.
View Article and Find Full Text PDFThe additive value of CA19.9 monitoring in a pancreatic cyst surveillance program.
United European Gastroenterol J
September 2023
Background: Surveillance of pancreatic cysts focuses on the detection of (mostly morphologic) features warranting surgery. European guidelines consider elevated CA19.9 as a relative indication for surgery.
View Article and Find Full Text PDFBackground And Aims: In high-risk individuals (HRIs), we aimed to assess the cumulative incidence of intraductal papillary mucinous neoplasms (IPMNs) and compare IPMN growth, neoplastic progression rate, and the value of growth as predictor for neoplastic progression to these in sporadic IPMNs.
Methods: We performed annual surveillance of Dutch HRIs, involving carriers of germline pathogenic variants (PVs) and PV-negative familial pancreatic cancer kindreds. HRIs with IPMNs were compared with Italian individuals without familial risk under surveillance for sporadic IPMNs.
Evidence supporting the effectiveness of pancreatic cancer (PC) screening is scant. Most clinical studies concern small populations with short follow-up durations. Mathematical models are useful to estimate long-term effects of PC screening using short-term indicators.
View Article and Find Full Text PDFBackground And Aims: To date, surveillance of high-risk individuals for pancreatic ductal adenocarcinoma (PDAC) has not lived up to expectations, as identification of curable stages through imaging remains challenging. Biomarkers are therefore needed. Pancreatic juice (PJ) may be a promising source, because it is in direct contact with the ductal epithelial lining from which PDAC arises.
View Article and Find Full Text PDFArticle Synopsis
- * In a study of 2552 high-risk individuals, 1% developed neoplastic progression to PC or high-grade dysplasia within an average follow-up of 29 months, often without prior detectable lesions.
- * Successful early detection was linked to the removal of cystic lesions and smaller lesions, highlighting the need for improved diagnostic tools to catch these issues sooner, as many cancers advanced before the next scheduled examination.
Objective: We aimed to determine the long-term yield of pancreatic cancer surveillance in hereditary predisposed high-risk individuals.
Design: From 2006 to 2019, we prospectively enrolled asymptomatic individuals with an estimated 10% or greater lifetime risk of pancreatic ductal adenocarcinoma (PDAC) after obligatory evaluation by a clinical geneticist and genetic testing, and subjected them to annual surveillance with both endoscopic ultrasonography (EUS) and MRI/cholangiopancreatography (MRI/MRCP) at each visit.
Results: 366 individuals (201 mutation-negative familial pancreatic cancer (FPC) kindreds and 165 PDAC susceptibility gene mutation carriers; mean age 54 years, SD 9.
Pancreatic cancer (PC) survival is poor, as detection usually occurs late, when treatment options are limited. Screening of high-risk individuals may enable early detection and a more favorable prognosis. Knowledge gaps prohibit establishing the effectiveness of screening.
View Article and Find Full Text PDFBackground And Aims: Patient-reported outcome measures are increasingly important in daily care and research in inflammatory bowel disease [IBD]. This study provides an overview of the content and content validity of IBD-specific patient-reported outcome measures on three selected constructs.
Methods: Databases were searched up to May 2019 for development and/or content validity studies on IBD-specific self-report measures on health-related quality of life, disability, and self-report disease activity in adults.