The Experiences of Native Irish speaking Older Adults Navigating Healthcare Services.

Aim: This research aims to understand the experiences of native Irish speaking older adults navigating healthcare services in Ireland.

Methods: Semi-structured interviews in the Irish language were conducted with seven participants. Interviews were audio recorded and transcribed.

Manipulation of the inflammatory reflex as a therapeutic strategy.

The cholinergic anti-inflammatory pathway is the efferent arm of the inflammatory reflex, a neural circuit through which the CNS can modulate peripheral immune responses. Signals communicated via the vagus and splenic nerves use acetylcholine, produced by Choline acetyltransferase (ChAT)+ T cells, to downregulate the inflammatory actions of macrophages expressing α7 nicotinic receptors. Pre-clinical studies using transgenic animals, cholinergic agonists, vagotomy, and vagus nerve stimulation have demonstrated this pathway's role and therapeutic potential in numerous inflammatory diseases.

Sexual assault and fatal violence against women during the Irish War of Independence, 1919-1921: Kate Maher's murder in context.

At the height of the Irish War of Independence, 1919-1921, 45-year-old Kate Maher was brutally raped. She subsequently died of terrible wounds, almost certainly inflicted by drunken British soldiers. This article discusses her inadequately investigated case in the wider context of fatal violence against women and girls during years of major political instability.

Expression of in the Stem Cell Domain Is Required for Its Function in the Control of Floral Meristem Activity in .

In the model plant , the zinc-finger transcription factor KNUCKLES (KNU) plays an important role in the termination of floral meristem activity, a process that is crucial for preventing the overgrowth of flowers. The gene is activated in floral meristems by the floral organ identity factor AGAMOUS (AG), and it has been shown that both AG and KNU act in floral meristem control by directly repressing the stem cell regulator (), which leads to a loss of stem cell activity. When we re-examined the expression pattern of in floral meristems, we found that is expressed throughout the center of floral meristems, which includes, but is considerably broader than the expression domain.

The utility of routine echocardiography in newborn infants with a persistent oxygen requirement.

In the era of antenatal screening for congenital heart disease (CHD), infants presenting with an undiagnosed significant CHD are rare. However, term infants admitted with an initial diagnosis of TTN and a prolonged oxygen requirement often undergo an echocardiogram. We aimed to assess whether this practice yields any additional cases of undiagnosed CHD.

Professional patienthood and mortality: Seán Ó Ríordáin's diaries 1974-1977.

Unwieldy by nature, unsolicited diaries and their study, this article contends, have the potential to offer deeper insights into the experience of illness but only if they receive due consideration from scholars. This article uses a series of historic diaries to examine the concept of 'professional patienthood' or being a full-time patient, and, while it found the narrative medicine approach to be very useful, it also found it limiting. The recent methodological trends in biomedicine and social sciences towards structured mechanisms like questionnaires-surveying and evaluating performance, satisfaction and experience-can only go so far.

Anthony Traill (1838-1914), the first Provost to confer degrees on Women Graduates.

Anthony Traill was born into a Scotch-Irish family at Ballylough House near Bushmills in county Antrim in November 1838. At the age of twenty he entered Trinity College Dublin to study engineering, but he was a professional student who passed through all the faculties and took legal and medical degrees in 1864-1870. He applied his knowledge of physics when advising his brother William who was building the Portrush-Bushmills electric railway.

Evarts Ambrose Graham (1883-1957), doyen of pulmonary surgeons.

Evarts Graham performed the first successful pneumonectomy in 1933. Evarts Ambrose Graham, the son of a Scotch Irish surgeon, was born on 19 March 1883. After early schooling in Chicago, he graduated at Princeton and returned to Chicago to study Medicine, taking his MD at Rush Medical College in 1907.

Franciscus Cornelis Donders (1818-1889).

Franciscus Cornelis Donders was educated at Duizel and Boxmeer before entering the Military Medical School and the medical faculty at Utrecht University in 1835. In 1840, he received his MD from Leiden and spent 2 years in practice at Vlissingen before returning to Utrecht, where he was appointed as an extraordinary professor to lecture on forensic medicine, anthropology, general biology and ophthalmology. Refraction by the eye is complex, since the ray of light passes through many changes of refractive index in its path, and Donders simplified the account of the process by establishing an equivalent refractive system: the reduced eye.

De Novo interstitial deletion 13q33.3q34 in a male patient with double outlet right ventricle, microcephaly, dysmorphic craniofacial findings, and motor and developmental delay.

We describe a 6-year-old male, diagnosed at birth with double outlet right ventricle (DORV), anterior aorta, multiple ventricular septal defects, pulmonary stenosis, microcephaly and mildly dysmorphic craniofacial findings. Chromosomal analysis showed a normal male karyotype but on subsequent array comparative genomic hybridization (array CGH) analysis a de novo 2.5 Mb loss in chromosome 13q at 13q33.

Diagnostic evaluation, monitoring, and perioperative management of spinal cord compression in patients with Morquio syndrome.

Mucopolysaccharidosis IVA is an autosomal recessive condition caused by mutations in the GALNS gene, which encodes N-acetylgalactosamine-6-sulfatase, also called galactosamine-6-sulfatase (GALNS). A reduction in or absence of effective GALNS leads to faulty catabolism of keratan sulfate and chondroitin-6-sulfate within the lysosome; their accumulation causes cell, tissue, and organ dysfunction. The connective tissue, cartilage, ligaments, and bone of patients with Morquio A syndrome are particularly affected.

Rapid regression of left ventricular outflow tract rhabdomyoma after sirolimus therapy.

The neonatal presentation of cardiac rhabdomyomas varies in severity from severe outflow tract obstruction to minimal cardiac dysfunction. The natural history for these lesions is spontaneous regression in the majority of cases. We describe a newborn boy with severe left ventricular outflow tract obstruction secondary to a large rhabdomyoma.

Robert Whytt (1714-1766): from dropsy in the brain to tuberculous meningitis.

Robert Whytt was born and educated in Edinburgh and served the City in the Royal Infirmary. A prolific author, his major work is usually said to be his Essay on the Vital and other Involuntary Movements of Animals (1751), based on his belief that a 'sentient principle' was not limited to the nervous system but was distributed throughout the body, a view that brought him into conflict with Albrecht von Haller, who held that the sentient and motor powers of the body were those of a machine. Whatever about the speculative nature of the sentient principle, Whytt was a clinician blessed with unusual clarity, and he is remembered today for his Observations on the Dropsy in the Brain (1768).

Joseph Erlanger (1874-1965): the cardiovascular investigator who won a Nobel Prize in neurophysiology.

Born in San Francisco in 1874 into the family of German immigrants in which he was the only one to proceed beyond elementary education, Joseph Erlanger graduated from the University of California (Berkeley) in 1894. He was about to enter the local Cooper Medical School when he was told that the new medical school in Johns Hopkins University (Baltimore) aimed to surpass all others, and there he graduated and was later coached for a career in academic life by William H Howell (1860-1945). In due course he held the Chairs of Physiology in the University of Wisconsin (Madison) and Washington University at St Louis, Missouri.

Medical officers, bodies, gender and weight fluctuation in irish convict prisons, 1877-95.

This article focuses on the function of the convict prison infirmary and views it as a site of arbitration, resistance and 'contested power'. In accordance with the rules and regulations periods of incarceration in convict prisons began and ended with an obligatory medical examination. While the primary function of the initial test was to measure the convict body in order ascertain physical ability to conduct hard labour it also provided a thorough bio-metrical description for future identification purposes.