Publications by authors named "Brayan Murillo-Castillo"
Pharmacy (Basel)
August 2022
Article Synopsis
- Metastatic colon cancer treatments often involve specific drug combinations like FOLFOX, CapeOX, and FOLFIRI, along with biological and immunotherapies, but their effectiveness can vary based on genetic mutations.
- Research highlights that mutations in genes such as RAS and RAF can lead to treatment resistance, while certain mutations in the DPDY gene may require dosage adjustments to minimize side effects.
- Understanding these genetic factors is crucial for oncologists to tailor treatments effectively and improve patient outcomes in colon cancer therapy.
Pharmaceutics
December 2021
Article Synopsis
- Chronic wounds require tailored therapies, leading to the development of a chitosan-based scaffold for 24-hour controlled release of Dexketoprofen trometamol (DKT).
- Three prototypes were created using different compositions (chitosan, chitosan:PVA, and chitosan:gelatin) and tested for compatibility and structure.
- The chitosan:gelatin formulation (F3) showed the best controlled release of DKT, maintaining effective drug delivery and minimizing initial burst release, making it a promising option for improving wound healing.
