Age-dependent differences in breast tumor microenvironment: challenges and opportunities for efficacy studies in preclinical models.

Immunity suffers a function deficit during aging, and the incidence of cancer is increased in the elderly. However, most cancer models employ young mice, which are poorly representative of adult cancer patients. We have previously reported that Triple-Therapy (TT), involving antigen-presenting-cell activation by vinorelbine and generation of TCF1-stem-cell-like T cells (scTs) by cyclophosphamide significantly improved anti-PD-1 efficacy in anti-PD1-resistant models like Triple-Negative Breast Cancer (TNBC) and Non-Hodgkin's Lymphoma (NHL), due to T-cell-mediated tumor killing.

A Double Compatibilization Strategy To Boost the Performance of -- Solar Cells Based on Perovskite Deposited in Humid Ambient Air.

Formamidinium lead iodide (FAPI) represents the most promising perovskite for single junction solar cells, exhibiting an impressive performance when deposited in a controlled nitrogen environment. In order to foster the real-world application of this technology, the deposition of FAPI in ambient air is a highly desirable prospect, as it would reduce fabrication costs. This study demonstrates that the wettability of FAPI precursors on the hole transporting layers (HTL) used to fabricate inverted -- solar cells is extremely poor in ambient air, hampering the realization of a perovskite active layer with good optoelectronic quality.

Resistive switching in benzylammonium-based Ruddlesden-Popper layered hybrid perovskites for non-volatile memory and neuromorphic computing.

Artificial synapses based on resistive switching have emerged as a promising avenue for brain-inspired computing. Hybrid metal halide perovskites have provided the opportunity to simplify resistive switching device architectures due to their mixed electronic-ionic conduction, yet the instabilities under operating conditions compromise their reliability. We demonstrate reliable resistive switching and synaptic behaviour in layered benzylammonium (BzA) based halide perovskites of (BzA)PbX composition (X = Br, I), showing a transformation of the resistive switching from digital to analog with the change of the halide anion.

Formamidinium Perovskite Deposition in Ambient Air Environment for Inverted p-i-n Solar Cells.

In order to move towards large-scale fabrication, perovskite solar cells need to detach themselves from strictly controlled environmental conditions and, to this end, fabrication in ambient air is highly desirable. Formamidinium iodide perovskite (FAPI) is one of the most promising perovskites but is also unstable at room temperature, which may make the ambient air deposition more difficult. Herein, we investigated different formulations of pure FAPI for the fabrication of perovskite solar cells (PSCs) in air.

Metronomic chemotherapy, dampening of immunosuppressive cells, antigen presenting cell activation, and T cells. A quartet against refractoriness and resistance to checkpoint inhibitors.

Chemotherapeutic agents have profound effects on cancer, stroma and immune cells that - in most cases - depend upon the dosage and schedule of administration. Preclinical and clinical studies summarized and discussed in the present review have demonstrated that maximum tolerable dosage (MTD) vs low-dosage, continuous (metronomic) administration of most chemotherapeutics have polarized effects on immune cells. In particular, metronomic schedules might be associated - among others effects - with activation of antigen presenting cells and generation of new T cell clones to enhance the activity of several types of immunotherapies.

XEN 45 Gel Stent Implantation in Open Angle Glaucoma: 5-Year Results of a Prospective Study.

Prcis: XEN 45 Gel Stent is safe and effective for 3 years. The study results provide useful insight into the outcome of XEN 45 Gel Stent surgery over 5 years in daily clinical practice.

Purpose: To evaluate 5-year outcomes of XEN 45 gel stent implantation (XEN) in patients with open angle glaucoma.

Comparison of Conventional and Femtosecond Laser-Assisted Cataract Surgery Regarding Macula Behavior and Thickness.

: The aim of the study was to compare macular thickness behavior and clinical outcomes after femtosecond laser-assisted cataract surgery (FLACS) versus phacoemulsification conventional surgery (PCS). : Macular Optical Coherence Tomography OCT was analyzed in 42 patients preoperatively, 1 day, 12 days, 4 weeks and 6 weeks postoperatively according to the 9-field Early Treatment Diabetic Retinopathy Study (ETDRS) grid. Clinical findings were collected in both the FLACS group and the PCS group.

Vinorelbine and Intermittent Cyclophosphamide Sensitize an Aggressive Myc-Driven B-Cell Lymphoma to Anti-PD-1 by an Immunological Memory Effective against Tumor Re-Challenge.

We have previously shown in triple-negative breast cancer (TNBC) models that a triple therapy (TT) including intermittent cyclophosphamide (C), vinorelbine (V), and anti-PD-1 activates antigen-presenting cells (APC) and generates stem like-T cells able to control local and metastatic tumor progression. In the present manuscript, we report the generation of a highly aggressive, anti-PD-1 resistant model of a high-grade, Myc-driven B-cell non-Hodgkin's lymphoma (NHL) that can be controlled in vivo by TT but not by other chemotherapeutic agents, including cytarabine (AraC), platinum (P), and doxorubicin (D). The immunological memory elicited in tumor-bearing mice by TT (but not by other treatments) can effectively control NHL re-challenge even at very high inoculum doses.

Bowman Layer Transplantation for Treating Keratoconus-Preliminary Findings.

(1) Background: Mid-stromal isolated Bowman layer transplantation aims to reduce and stabilize corneal ectasia in patients with advanced, progressive keratoconus. The purpose of this review is to evaluate the effectiveness and safety of this new surgical technique. (2) Methods: Following the PRISMA statement and checklist, we searched Medline, the Cochrane Controlled Trials Register, and Embase and used a broad systematic search strategy according to the Cochrane Collaboration.

Outcomes of Deep Sclerectomy following Failed XEN Gel Stent Implantation in Open-Angle Glaucoma: A Prospective Study.

Background: The purpose of this study is to evaluate the outcome of deep sclerectomy (DS) as a secondary procedure following failed ab-interno XEN gel stent implantation in patients with open-angle glaucoma. Methods: Prospective, single-center, non-randomized, interventional study. Consecutive eyes that underwent mitomycin C (MMC) augmented XEN gel stent surgery, with uncontrolled intraocular pressure (IOP) or signs of disease progression, were included to undergo MMC-augmented DS.

Surgical outcomes of excisional goniotomy using the kahook dual blade in severe and refractory glaucoma: 12-month results.

Objectives: To describe the efficacy and safety of goniotomy with trabecular meshwork excision using the Kahook Dual Blade (KDB, New World Medical Inc., Rancho Cucamonga, CA) in patients with severe or refractory glaucoma.

Methods: This retrospective multicentre case series reports on 40 eyes with severe or refractory open-angle glaucoma that underwent standalone or combined KDB goniotomy and were followed for 12 months post-operatively in the United-States, Mexico and Switzerland.

Acute Serous Retinal Detachment after the Same Operating Session of Uncomplicated Cataract Surgeries: A Case Series.

Purpose: To report four cases of acute serous retinal detachment (ASRD) after the same operating session of uncomplicated cataract surgeries.

Methods: In this case series, data of patients who developed ASRD after uncomplicated phacoemulsification with intraocular lens implantation during the same operating session were collected. Diagnosis was made on the first postoperative day, when all patients had a very low best-corrected visual acuity (BCVA), despite a good aspect of the anterior segment, without significant keratopathy and with only trace cells in the anterior chamber.

Inclusion of 2D Transition Metal Dichalcogenides in Perovskite Inks and Their Influence on Solar Cell Performance.

Organic-inorganic hybrid perovskite materials have raised great interest in recent years due to their excellent optoelectronic properties, which promise stunning improvements in photovoltaic technologies. Moreover, two-dimensional layered materials such as graphene, its derivatives, and transition metal dichalcogenides have been extensively investigated for a wide range of electronic and optoelectronic applications and have recently shown a synergistic effect in combination with hybrid perovskite materials. Here, we report on the inclusion of liquid-phase exfoliated molybdenum disulfide nanosheets into different perovskite precursor solutions, exploring their influence on final device performance.

Bilateral Nonpenetrating Deep Sclerectomy: Difference in Outcomes Between First- and Second-Operated Eyes at 24 Months.

Background/aim: The aim of this study was to assess the difference in outcome between the first-operated and the second-operated eyes after nonpenetrating deep sclerectomy (DS), and to identify potential success predictors for the second eye.

Methods: This single-surgeon, retrospective study analyzed the outcomes of all bilateral nonsimultaneous DS with at least 24 months of follow-up. Its main outcome measure was surgical success, defined as unmedicated intraocular pressure (IOP) ≤15 mm Hg associated with a relative reduction ≥20%.

Combined and stand-alone XEN 45 gel stent implantation: 3-year outcomes and success predictors.

Purpose: To evaluate the 3-year treatment outcomes of XEN 45 gel stent in open-angle glaucoma patients.

Methods: In this prospective, single-centre interventional study, consecutive eyes with uncontrolled intraocular pressure (IOP) or signs of disease progression despite medical treatment underwent XEN implantation either alone or combined with phacoemulsification (Phaco + XEN).

Main Outcome Measures: Surgical success was defined as 'complete' when 36-month unmedicated IOP was ≤15 mmHg with a relative IOP reduction ≥ 20% from medicated baseline, while the definition of qualified success allowed no more medications than at baseline.

Iridocorneal Angle Assessment After Laser Iridotomy With Swept-source Optical Coherence Tomography.

Aim: To investigate the reliability of anterior chamber angle (ACA) measurements in narrow angles and assess the effect of laser peripheral iridotomy (LPI) on these measurements using novel swept-source optical coherence tomography (SS-OCT) technology.

Materials And Methods: In this prospective observational study, patients with gonioscopically narrow angles were enrolled and scheduled for prophylactic LPI. Twelve ACA sections were obtained in each eye using SS-OCT (ANTERION, Heidelberg Engineering, Germany) before and after Nd:YAG LPI.

A Prospective Analysis of iStent Inject Microstent Implantation: Surgical Outcomes, Endothelial Cell Density, and Device Position at 12 Months.

Precis: The surgical outcome of iStent inject devices is associated with device protrusion within the anterior chamber. Schlemm canal (SC) dilatation has a prognostic value. iStent inject devices do not move within the first year after implantation.

Delayed Obstruction of XEN Gel Stent by Cell Debris in Primary Open-angle Glaucoma: A New Insight into the Pathophysiology of Filtration Device Failure.

Aim: The aim of this report is to explore the risk factors of XEN stent obstruction, suggesting the need for a stricter control of these factors and highlighting areas for further research.

Background: Despite its proven effectiveness and safety profile, XEN gel stents (Allergan Plc, Dublin, Ireland) can become obstructed. The causes and predicting factors for such obstructions still require further research.

Baerveldt-Baerveldt Apposition: A New Surgical Technique to Salvage Obstructed Glaucoma Drainage Tubes.

Aim: Glaucoma drainage device (GDD) failure is usually rectified by the replacement of the entire device or using a tube extender, both of which were associated with postoperative complications. To minimize these risks, we developed a technique to replace the failing section of a tube while keeping the filtration plate in place, and without resorting to an extender clip.

Background: We describe the case of a 69-year-old man, whose left posttraumatic glaucoma was initially treated with a XEN-augmented Baerveldt procedure.