Publications by authors named "Brassesco M"

Tumor heterogeneity poses a significant challenge in osteosarcoma (OS) treatment. In this regard, the "omics" era has constantly expanded our understanding of biomarkers and altered signaling pathways (i.e.

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  • - The study focused on treatment experiences for kids with NTRK-fused tumors, looking at access to care, how they responded to treatment, side effects, and overall health outcomes.
  • - Researchers reviewed data from 17 pediatric cases treated with larotrectinib, identifying six NTRK fusion subtypes and noting that 11 of 14 patients had positive tumor responses, with various levels of adverse effects reported.
  • - The findings suggest that larotrectinib is effective for treating these tumors in children, but challenges still exist in ensuring consistent access to treatment, particularly in countries with limited resources like Brazil.
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Estrogen deficiency, long-term immobilization, and/or aging are commonly related to bone mass loss, thus increasing the risk of fractures. One option for bone replacement in injuries caused by either traumas or pathologies is the use of orthopedic cement based on polymethylmethacrylate (PMMA). Nevertheless, its reduced bioactivity may induce long-term detachment from the host tissue, resulting in the failure of the implant.

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The medical device industry is undergoing substantial transformations, looking to face the increasing pressures on healthcare systems and fundamental shifts in healthcare delivery. There is an ever-growing emphasis on identifying underserved clinical requirements and enhancing industry-academia partnerships to accelerate innovative solutions. In this context, an analysis of the requirements for translation, highlighting support and funding for innovation to transform an idea for a biomaterial device into a commercially available product, is discussed.

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  • Identifying bioactive molecules from marine organisms, particularly fish, remains largely unexplored, despite their potential benefits.
  • Analysis of the Lusitanian toadfish's crude body mucus showed promising antioxidant, antihypertensive, and antimicrobial properties, with specific metrics indicating strong activity levels.
  • This study is the first to highlight the bioactive potential of toadfish mucus, suggesting its possible applications in food and pharmaceuticals.
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Despite being rich in starch, over half of acorn production is undervalued. High hydrostatic pressure was used to modify the properties of (0.1 and 460 MPa for 20 min) and (0.

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  • Childhood cancer, though rare, leads to significant mortality, with a child dying from cancer every 3 minutes globally, highlighting the need for better treatment options.
  • The study focuses on analyzing kinase functionality in pediatric solid tumors, exploring their expression patterns and correlation with clinical outcomes, as well as investigating the effectiveness of kinase inhibitors.
  • A review of small molecules targeting kinases and their potential clinical applications is provided, while addressing challenges such as lack of specific compounds for childhood cancers and issues with resistance.
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Purpose: While pediatric glioblastomas are molecularly distinct from adult counterparts, the activation of NF-kB is partially shared by both subsets, playing key roles in tumor propagation and treatment response.

Results: We show that, in vitro, dehydroxymethylepoxyquinomicin (DHMEQ) impairs growth and invasiveness. Xenograft response to the drug alone varied according to the model, being more effective in KNS42-derived tumors.

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The peels of many fruits are rich sources of nutrients, although they are not commonly consumed. If they are properly decontaminated, they can be used as healthy food ingredients reducing food waste. The objective was to apply thermosonication processes to kiwi peel and evaluate the impact on survival (a non-pathogenic surrogate of ) and key nutrients and quality indicators: proteins, fibers, minerals (Ca, K, Mg, Na, and P), chlorophylls, and phenolic contents.

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  • * A comprehensive review and data analysis from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) confirmed varying expression levels of miR-708 in different tumors, highlighting its dual profile as some tumors showed high expression while others had low.
  • * Investigation of miR-708's targets revealed 572 genes involved in crucial pathways like PI3K-Akt and p53 signaling, showcasing it as a potential diagnostic marker, but its therapeutic application is limited due to complex functions and
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Carob fruit is native to the Mediterranean region and produced mainly in Portugal, Italy, Morocco and Turkey. The production of the carob fruit in Portugal is highly extensive and sustainable. Currently, carob flour (CF) production is mainly achieved after pulp separation, despite it having been demonstrated that the seeds improve the extraction efficiency of bioactive compounds such as polyphenols, promoting human health.

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Polymethylmethacrylate (PMMA)-based cements are used for bone reparation due to their biocompatibility, suitable mechanical properties, and mouldability. However, these materials suffer from high exothermic polymerization and poor bioactivity, which can cause the formation of fibrous tissue around the implant and aseptic loosening. Herein, we tackled these problems by adding Sr -substituted hydroxyapatite nanoparticles (NPs) and a porogenic compound to the formulations, thus creating a microenvironment suitable for the proliferation of osteoblasts.

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Background: There is evidence to suggest that long term exposure to air pollution could be associated with decreased levels of fertility, although there is controversy as to how short term exposure may compromise fertility in IVF patients and what windows of exposure during the IVF process patients could be most vulnerable.

Methods: This prospective cohort study aimed to evaluate the impact of acute exposure that air pollution have on reproductive outcomes in different moments of the IVF process. Women undergoing IVF living in Barcelona were recruited.

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The current food system is directly influenced by the increase in environmental problems and nutritional inequality globally. Financial and political collapses, health crises, excessive urbanization, and rapid industrialization are some of the principal factors threatening the food supply's security. The food system needs a profound transformation to avoid ecosystem destabilization and a global food crisis.

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  • Despite understanding the biology of pediatric CNS malignancies, prognosis for patients remains poor.
  • This review focuses on the NF-kB signaling pathway, which is often disrupted in cancer and impacts cell growth and treatment resistance.
  • It discusses various NF-kB inhibitors and their potential in improving treatment outcomes for common pediatric CNS tumors like gliomas, medulloblastomas, and ependymomas.
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  • HnRNP K protein is linked to the development of acute promyelocytic leukemia (APL) and its differentiation process when treated with all-trans retinoic acid (ATRA), showing significant mRNA levels in APL patients at diagnosis.
  • The study explored the roles of hnRNP K and SET proteins in APL, finding that knocking down hnRNP K led to cell death and increased granulocytic differentiation, especially in ATRA-resistant cells.
  • Combination treatments involving arsenic trioxide and an ERK inhibitor demonstrated enhanced effects against tumor growth, suggesting that targeting hnRNP K, SET, and related pathways could improve therapies for APL and drug-resistant cases.
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Although ependymoma (EPN) molecular subgroups have been well established by integrated high-throughput platforms, low- and middle-income countries still need low-cost techniques to promptly classify these molecular subtypes. Here, we applied low-cost methods to classify EPNs from a Brazilian cohort with 60 pediatric EPN patients. Fusion transcripts (C11orf95-RELA, YAP1-MAMLD1, and YAP1-FAM118B) were investigated in supratentorial EPN (ST-EPNs) samples through RT-PCR/Sanger sequencing and immunohistochemistry (IHC) for p65/L1CAM.

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Purpose: Inhalation of perillyl alcohol (POH) recently emerged as an investigational promising antiglioma strategy. However, little attention has been paid to its therapeutic potential for other brain tumors, especially in the pediatric setting.

Methods: The effects of POH were explored in medulloblastoma cell models belonging to the SHH variant with activation of RAS (ONS-76) or with TP53 mutations (DAOY and UW402), by means of proliferation and invasion assays.

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Research Question: Does a freeze-all strategy improve live birth rates in women of different age groups?

Design: Retrospective cohort study of 1882 first embryo transfer cycles, performed between January 2013 and December 2015. Reproductive outcomes between fresh (FRESH) or frozen (FROZEN) embryo transfers were compared in patients stratified by age: < 35, between 35 and 38, or > 38 years. Student's t test for independent samples and χ analyses were used as needed.

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Cancer targeted therapy, either alone or in combination with conventional chemotherapy, could allow the survival of patients with neoplasms currently considered incurable. In recent years, the dysregulation of the Rho-associated coiled-coil kinases (ROCK1 and ROCK2) has been associated with increased metastasis and poorer patient survival in several tumor types, and due to their essential roles in regulating the cytoskeleton, have gained popularity and progressively been researched as targets for the development of novel anti-cancer drugs. Nevertheless, in a pediatric scenario, the influence of both isoforms on prognosis remains a controversial issue.

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Photoacoustic imaging (PAI) combines optical contrast with ultrasound spatial resolution and can be obtained up to a depth of a few centimeters. Hand-held PAI systems using linear array usually operate in reflection mode using a dark-field illumination scheme, where the optical fiber output is attached to both sides of the elevation plane (short-axis) of the transducer. More recently, bright-field strategies where the optical illumination is coaxial with acoustic detection have been proposed to overcome some limitations of the standard dark-field approach.

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Introduction: Pilocytic astrocytoma (PA) is the most common brain tumor that affects the pediatric population. Even though PA is benign and treatment only involves surgery, recurrent or unresectable tumors require chemo- and radiotherapy. Besides BRAF, CDKN2A, or IDH mutations, the hyperactivation of the nuclear factor NF-κB contributes to tumor growth and survival.

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Abdominal tumors (AT) in children account for approximately 17% of all pediatric solid tumor cases, and frequently exhibit embryonal histological features that differentiate them from adult cancers. Current molecular approaches have greatly improved the understanding of the distinctive pathology of each tumor type and enabled the characterization of novel tumor biomarkers. As seen in abdominal adult tumors, microRNAs (miRNAs) have been increasingly implicated in either the initiation or progression of childhood cancer.

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