Mental health disorders are among the top leading causes of disease burden worldwide and many patients have high levels of treatment resistance. Even though medications offer improvement to some patients, antidepressants are only effective in about half of those treated, and schizophrenia is treatment-refractory in about one-third of patients. One way to combat this disparity is to improve medication development and discovery for psychiatric disorders through evidence-based research.
View Article and Find Full Text PDFTraditional retrograde intubation consists of tracheal intubation performed over a guide wire inserted into the trachea inferior to the vocal cords and then passed transorally or transnasally. This intubation technique is reserved for patients with a difficult airway when other methods such as blind nasal intubation or video laryngoscopy fail. A guide wire passed blindly in a retrograde fashion, however, is not without its own constraints.
View Article and Find Full Text PDFFast radio bursts (FRBs) are brief, bright, extragalactic radio flashes. Their physical origin remains unknown, but dozens of possible models have been postulated. Some FRB sources exhibit repeat bursts.
View Article and Find Full Text PDFA pharmacy medication titration clinic helped patients with chronic heart failure successfully reach target doses.
View Article and Find Full Text PDFBackground: Disease management programs for heart failure (HF) effectively reduce HF-related hospitalization rates and mortality. Shared medical appointments (SMAs) offer a cost-effective delivery method for HF disease management programs. However, few studies have evaluated this cost-effective delivery method of HF disease management among Veterans with acute HF.
View Article and Find Full Text PDFBackground: The use of N-acetylcysteine for the prevention of contrast-induced nephropathy has been the subject of numerous clinical trials and meta-analyses. We sought to examine the possibility of a publication bias and whether meta-analyses have magnified any potential publication bias.
Methods: We performed a Medline search and a manual search to identify published manuscripts.