HMGA2-mediated tumorigenesis through angiogenesis in leiomyoma.

Objective: To study the role of HMGA2 in promoting angiogenesis in uterine leiomyoma (LM).

Design: This study involved evaluation of vessel density and angiogenic factors in leiomyomas with HMGA2 overexpression; examining angiogenic factor expression and AKT signaling in myometrial (MM) and leiomyoma cells by introducing HMGA2 overexpression in vitro; and exploring vessel formation induced by HMGA2 overexpression both in vitro and in vivo.

Setting: University research laboratory.