Oxidative stress and paraoxonase 1 status in acute ischemic stroke patients.

Objective: The connection of oxidative stress with dyslipidemia creates a newly-emerging atherosclerosis risk factor involved in acute ischemic stroke development. This study analyzed the influence of oxidative stress on structural changes of high-density lipoprotein (HDL) particles connected with modification in protective paraoxonase 1 (PON1) activity.

Methods: This study used 185 patients with acute ischemic stroke and 185 apparently healthy controls.

LDL and HDL subclasses in acute ischemic stroke: prediction of risk and short-term mortality.

Objective: Small, dense low-density lipoprotein (sdLDL) and small-sized high-density lipoprotein (HDL) particles are established risk factors for ischemic heart disease. However, their clinical significance for acute ischemic stroke (AIS) is uncertain. This study evaluates associations of LDL and HDL particle sizes and subclasses with AIS risk and short-term mortality after AIS.