Investigation of the Antinociceptive Activity of the Hydroethanolic Extract of Leaf by the Tail-Immersion and Formalin Pain Tests in Rats.

Background: leaf is obtained from a plant that is used in traditional medicine in some countries to alleviate inflammatory diseases.

Aim: The aim of this study was to compare the effects of extract on acute nociceptive and inflammatory pain in rats.

Methods: Antinociceptive activity was examined in Wistar rats by the tail-immersion and formalin tests.

Chloroquine Attenuates Oxidative Stress in Gentamicin-Induced Nephrotoxicity in Rats.

The wider application of gentamicin is limited by potential adverse effects (nephrotoxicity and ototoxicity). The goal of our study was to investigate the effects of chloroquine on biochemical and oxidative stress parameters in gentamicin-induced nephrotoxicity in rats. Animals were randomly divided into 1 of 5 groups.

Chronic estradiol exposure modulates thyroid structure and decreases T4 and T3 serum levels in middle-aged female rats.

Objectives: In human medicine, estrogen is applied in prevention and treatment of health problems associated with the menopause. The aim of this study was to examine the effects of chronic estradiol dipropionate (EDP) treatment on thyroid gland structure and function in middle-aged female rats.

Methods: At 14 months of age, Wistar rats received 0.

Somatostatin affects morphology and secretion of pituitary luteinizing hormone (LH) cells in male rats.

The somatostatin peptides (SRIH-14, SRIH-28) and their multiple receptors are generally associated with anti-proliferative and anti-secretory actions. This study compared, using standard morphometric measurements and terminal serum LH concentrations, effects of intracerebroventricular (icv) SRIH-14 and SRIH-28 in nanomolar amounts on immunohistochemically identified LH cells in pituitary glands of male rats. Rats received l microg/5 microl of SRIH-14 or SRIH-28 icv on days 1,3, and 5, whereas control rats received only icv saline.