Publications by authors named "Brandy-Lee A Soos"
Article Synopsis
- p62/Sequestosome 1 (p62) functions as both an autophagy receptor and a signaling platform, but how these roles are coordinated is unclear.
- TAK1, a kinase linked to immune signaling, negatively impacts p62's role in autophagy by reducing its presence in autophagosomes and promoting its relocalization into cytoplasmic bodies.
- This dynamic interaction between TAK1 and p62 suggests that TAK1 can shift p62's function from facilitating autophagy to acting as a signaling platform, potentially allowing the accumulation of certain autophagic substrates when necessary for cell functions.
