Publications by authors named "Brandt P Graham"
J Am Chem Soc
September 2024
Article Synopsis
- - Hyoscyamine 6β-hydroxylase (H6H) is an enzyme that uses iron and 2-oxoglutarate to convert hyoscyamine into the antinausea drug scopolamine through a two-step process involving hydroxylation and epoxidation.
- - The enzyme first performs hydroxylation at the C6 position before coupling it to the C7 position, but the mechanism of how H6H prefers this route over simply hydroxylating at C7 is unclear.
- - Research shows that H6H does not rely on substrate positioning for epoxidation; instead, a small angle change in how the iron approaches the substrate influences whether it performs hydroxylation
