Publications by authors named "Brandon Shu Huang Low"
Targeting Canonical Wnt-signaling Through GSK-3β in Arrhythmogenic Cardiomyopathy: Conservative or Progressive?
J Cardiovasc Transl Res
October 2024
Article Synopsis
- Arrhythmogenic cardiomyopathy (ACM) is a serious heart condition that can lead to sudden death and is influenced by various biological pathways, particularly the Wnt signaling pathway.
- GSK3β is a key enzyme in this pathway, and research indicates that blocking it could potentially protect against or reverse the harmful symptoms of ACM in experimental settings.
- The upcoming phase 2 TaRGET clinical trial will assess the effectiveness of GSK3β inhibition in ACM patients, while weighing its possible risks, such as arrhythmias and cancer.