Publications by authors named "Brandon Sebou"
Article Synopsis
- - Centrosome number is crucial for maintaining spindle bipolarity and genomic integrity during cell division, with ZYG-1/Plk4 being the key regulator for centrosome assembly.
- - Casein kinase II (CK2) plays a negative regulatory role by phosphorylating ZYG-1, impacting its levels and preventing excess centrosome duplication.
- - Depleting CK2 or preventing its phosphorylation of ZYG-1 results in increased levels of ZYG-1 at centrosomes, leading to centrosome amplification, highlighting the importance of CK2 in controlling centrosome number through protein degradation.
Spindle bipolarity is critical for genomic integrity. Given that centrosome number often dictates mitotic bipolarity, tight control of centrosome assembly is vital for the fidelity of cell division. The kinase ZYG-1/Plk4 is a master centrosome factor that is integral for controlling centrosome number and is modulated by protein phosphorylation.
View Article and Find Full Text PDFAberrant centrosome numbers are associated with human cancers. The levels of centrosome regulators positively correlate with centrosome number. Thus, tight control of centrosome protein levels is critical.
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