The pan-genome of Aspergillus fumigatus provides a high-resolution view of its population structure revealing high levels of lineage-specific diversity driven by recombination.

Aspergillus fumigatus is a deadly agent of human fungal disease where virulence heterogeneity is thought to be at least partially structured by genetic variation between strains. While population genomic analyses based on reference genome alignments offer valuable insights into how gene variants are distributed across populations, these approaches fail to capture intraspecific variation in genes absent from the reference genome. Pan-genomic analyses based on de novo assemblies offer a promising alternative to reference-based genomics with the potential to address the full genetic repertoire of a species.

Investigating and modeling the effect of light intensity on Rhodopseudomonas palustris growth.

Photosynthetic bacteria can be useful biotechnological tools-they produce a variety of valuable products, including high purity hydrogen, and can simultaneously treat recalcitrant wastewaters. However, while photobioreactors have been designed and modeled for photosynthetic algae and cyanobacteria, there has been less work on understanding the effect of light in photosynthetic bacterial fermentations. To design photobioreactors, and processes using these organisms, robust models of light penetration, utilization, and conversion are needed.

Host Lung Environment Limits Aspergillus fumigatus Germination through an SskA-Dependent Signaling Response.

Aspergillus fumigatus isolates display significant heterogeneity in growth, virulence, pathology, and inflammatory potential in multiple murine models of invasive aspergillosis. Previous studies have linked the initial germination of a fungal isolate in the airways to the inflammatory and pathological potential, but the mechanism(s) regulating A. fumigatus germination in the airways is unresolved.

Aspergillus fumigatus In-Host HOG Pathway Mutation for Cystic Fibrosis Lung Microenvironment Persistence.

The prevalence of Aspergillus fumigatus colonization in individuals with cystic fibrosis (CF) and subsequent fungal persistence in the lung is increasingly recognized. However, there is no consensus for clinical management of A. fumigatus in CF individuals, due largely to uncertainty surrounding A.

Aspergillus fumigatus Strain-Specific Conidia Lung Persistence Causes an Allergic Broncho-Pulmonary Aspergillosis-Like Disease Phenotype.

is a filamentous fungus which can cause multiple diseases in humans. Allergic broncho-pulmonary aspergillosis (ABPA) is a disease diagnosed primarily in cystic fibrosis patients caused by a severe allergic response often to long-term colonization in the lungs. Mice develop an allergic response to repeated inhalation of spores; however, no strains have been identified that can survive long-term in the mouse lung and cause ABPA-like disease.

Stork data scheduler: mitigating the data bottleneck in e-Science.

In this paper, we present the Stork data scheduler as a solution for mitigating the data bottleneck in e-Science and data-intensive scientific discovery. Stork focuses on planning, scheduling, monitoring and management of data placement tasks and application-level end-to-end optimization of networked inputs/outputs for petascale distributed e-Science applications. Unlike existing approaches, Stork treats data resources and the tasks related to data access and movement as first-class entities just like computational resources and compute tasks, and not simply the side-effect of computation.