Publications by authors named "Brandon Rafael de Jesus Castillo-Corea"
Article Synopsis
- Shrimp aquaculture faces significant challenges from infectious diseases like acute hepatopancreatic necrosis disease (AHPND) and white spot disease (WSD), making it crucial to understand the molecular mechanisms behind these diseases for better management.
- A new gene called arrestin domain containing-3 (LvARRDC3) was identified as playing a significant role in the development of AHPND and WSD, influencing viral gene expression and pathogen interactions.
- Manipulating LvARRDC3's expression through RNA silencing or overexpression showed a direct impact on the severity of infections, suggesting its potential as a target for disease control and a biomarker for improving shrimp breeding practices.
In WSSV pathogenesis, the molecular mechanisms and the key host factors that regulate the viral replication and morphogenesis remain unclear. However, like most viruses, WSSV is known to induce metabolic reprogramming in several metabolic pathways including the host glutamine metabolism, and several recent reports have suggested that the sirtuins SIRT3, SIRT4, and SIRT5, which belong to a family of NAD-dependent deacetylases, play an important role in this regulation. Here we focus on characterizing LvSIRT4 from Litopenaeus vannamei and investigate its role in regulating glutamine dehydrogenase (GDH), an important enzyme that promotes glutaminolysis and viral replication.
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