Screening for Quality of Life in a Neurology Tic Clinic Using Quality Improvement Methodology.

Background: Tic disorders in children often co-occur with other disorders that can significantly impact functioning. Screening for quality of life (QoL) can help identify optimal treatment paths. This quality improvement (QI) study describes implementation of a QoL measure in a busy neurology clinic to help guide psychological intervention for patients with tics.

Two self-similar Reynolds-stress transport models with anisotropic eddy viscosity.

Two Reynolds-averaged Navier-Stokes models with full Reynolds-stress transport (RST) and tensor eddy viscosity are presented. These new models represent RST extensions of the k-2L-a-C and k-ϕ-L-a-C models by Morgan [Phys. Rev.

Psychometric properties of the Burnout Assessment Tool across four countries.

Background: The Burnout Assessment Tool (BAT) is a new burnout measure developed to replace the Maslach Burnout Inventory (MBI). Studies have supported the psychometric properties and cross-cultural measurement invariance of the BAT. However, some unresolved questions remain.

Large-eddy simulation and Reynolds-averaged Navier-Stokes modeling of three Rayleigh-Taylor mixing configurations with gravity reversal.

High-fidelity large-eddy simulation (LES) is performed of Rayleigh-Taylor (RT) mixing in three different configurations involving gravity reversal. In each configuration, LES results are compared with one-dimensional Reynolds-averaged Navier-Stokes (RANS) results, and a deficiency in a commonly used transport equation for the mass-flux velocity, a_{j}, is identified. In the first configuration, a classical two-component RT mixing layer is allowed to develop before it is subjected to rapid acceleration reversal.

Simulation and Reynolds-averaged Navier-Stokes modeling of a three-component Rayleigh-Taylor mixing problem with thermonuclear burn.

Rayleigh-Taylor mixing in the presence of a third component with intermediate density is investigated through three-dimensional large-eddy simulation (LES) with a high-order compact finite-difference code. Two configurations are considered: (1) a symmetric configuration in which the Atwood number between the heavy and intermediate components matches the Atwood number between the intermediate and light components and (2) an asymmetric configuration in which the Atwood number between the heavy and intermediate components is an order of magnitude greater than the Atwood number between the intermediate and light components. Mass fraction covariances are extracted, and proposed Reynolds-averaged Navier-Stokes (RANS) closures for density-specific-volume and density-mass-fraction covariances are evaluated in an a priori fashion.

Self-consistent, high-order spatial profiles in a model for two-fluid turbulent mixing.

A Reynolds-averaged Navier-Stokes model is presented with the property that it admits self-consistent, high-order spatial profiles in simulations of two-fluid turbulent mixing layers. Whereas previous models have been limited by the assumption of a linear mixing profile, the present paper relaxes this assumption and, as a result, is shown to achieve much better agreement with experimental profiles. Similarity analysis is presented to derive constraints on model coefficients to enforce desired self-similar growth rates that are fully consistent with the high-order spatial profiles.

Scalar mixing in a Kelvin-Helmholtz shear layer and implications for Reynolds-averaged Navier-Stokes modeling of mixing layers.

Large-eddy simulation of a temporally evolving Kelvin-Helmholtz (KH) mixing layer is performed with the tenth-order compact difference code miranda to examine the steady-state behavior of a passive scalar in a shear-driven mixing layer. It is shown that the integral behavior of scalar variance in a KH mixing layer behaves similarly to the integral behavior of scalar variance in a Rayleigh-Taylor (RT) mixing layer, and mixedness of the simulated KH shear layer tends towards a value of about 0.8.

DRY NEEDLING IN THE MANAGEMENT OF PATIENTS MEETING CLINICAL DIAGNOSTIC CRITERIA FOR SUBACROMIAL PAIN SYNDROME: A CASE SERIES.

Background: Physical therapy interventions of exercise and manual therapy provide benefit in treatment of subacromial pain syndrome (SAPS). Dry needling is an emerging technique for treating musculoskeletal conditions; however, conflicting investigative evidence exists regarding the use of dry needling for SAPS.

Purpose: The purpose of this case series was to describe the use of dry needling, in conjunction with exercise, as a management strategy for patients meeting clinical diagnostic criteria of SAPS and to observe the short- and intermediate-term effects of dry needling with therapeutic exercise in this population.

Direct numerical simulation and Reynolds-averaged Navier-Stokes modeling of the sudden viscous dissipation for multicomponent turbulence.

Simulations of a turbulent multicomponent fluid mixture undergoing isotropic deformations are carried out to investigate the sudden viscous dissipation. This dissipative mechanism was originally demonstrated using simulations of an incompressible single-component fluid [S. Davidovits and N.

Self-consistent feedback mechanism for the sudden viscous dissipation of finite-Mach-number compressing turbulence.

Previous work [Davidovits and Fisch, Phys. Rev. Lett.

Two-length-scale turbulence model for self-similar buoyancy-, shock-, and shear-driven mixing.

The three-equation k-L-a turbulence model [B. Morgan and M. Wickett, Three-equation model for the self-similar growth of Rayleigh-Taylor and Richtmyer-Meshkov instabilities, Phys.

Systematic Clinical Reasoning in Physical Therapy (SCRIPT): Tool for the Purposeful Practice of Clinical Reasoning in Orthopedic Manual Physical Therapy.

Background And Purpose: Clinical reasoning is essential to physical therapist practice. Solid clinical reasoning processes may lead to greater understanding of the patient condition, early diagnostic hypothesis development, and well-tolerated examination and intervention strategies, as well as mitigate the risk of diagnostic error. However, the complex and often subconscious nature of clinical reasoning can impede the development of this skill.

Three-equation model for the self-similar growth of Rayleigh-Taylor and Richtmyer-Meskov instabilities.

In the present work, the two-equation k-L model [G. Dimonte and R. Tipton, Phys.

Resveratrol improves left ventricular diastolic relaxation in type 2 diabetes by inhibiting oxidative/nitrative stress: in vivo demonstration with magnetic resonance imaging.

Resveratrol is a natural phytophenol that exhibits cardioprotective effects. This study was designed to elucidate the mechanisms by which resveratrol protects against diabetes-induced cardiac dysfunction. Normal control (m-Lepr(db)) mice and type 2 diabetic (Lepr(db)) mice were treated with resveratrol orally for 4 wk.

TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction.

TEA domain transcription factor-1 (TEAD-1) is essential for proper heart development and is implicated in cardiac specific gene expression and the hypertrophic response of primary cardiomyocytes to hormonal and mechanical stimuli, and its activity increases in the pressure-overloaded hypertrophied rat heart. To investigate whether TEAD-1 is an in vivo modulator of cardiac specific gene expression and hypertrophy, we developed transgenic mice expressing hemagglutinin-tagged TEAD-1 under the control of the muscle creatine kinase promoter. We show that a sustained increase in TEAD-1 protein leads to an age-dependent dysfunction.

Enhancement of in vivo and in vitro immune functions by a conformationally biased, response-selective agonist of human C5a: implications for a novel adjuvant in vaccine design.

A conformationally biased, agonist of human C5a(65-74) (EP67) was assessed for its adjuvant activities in vitro and in vivo. EP67 induced the release of the inflammatory (Th1) type cytokines from C5a receptor (CD88)-bearing antigen presenting cells (APC). EP67 did not induce the release of these cytokines from splenic APCs obtained from C5a receptor knockouts (CD88(-/-)).