Monitoring subcellular biotransformation of N-L-leucyldoxorubicin by micellar electrokinetic capillary chromatography coupled to laser-induced fluorescence detection.

Development of prodrugs is a promising alternative to address cytotoxicity and nonspecificity of common anticancer agents. N-L-leucyldoxorubicin (LeuDox) is a prodrug that is biotransformed to the anticancer drug doxorubicin (Dox) in the extracellular space; however, its biotransformation may also occur intracellularly in endocytic organelles. Such organelle-specific biotransformation is yet to be determined.

Does the center of resistance depend on the direction of tooth movement?

Introduction: The objective of this study was to compare the locations of the centers of resistance (CRes) in the buccolingual (BL) and mesiodistal (MD) directions of the mandibular central incisors of 6 dogs.

Methods: Based on microcomputed tomography images of the teeth and their supporting tissues, solid models were used to build finite element models.

Results: The CRes locations for the 6 specimens were determined for displacements in the BL and MD directions with finite element calculations.