An Incidence of Duplicated Princeps Pollicis and Radialis Indicis Arteries.

The princeps pollicis artery (PPA) is typically a direct branch off the deep palmar arterial arch. Identified is a 90-year-old female cadaver in which the right hand has a duplicated PPA and radialis indicis (RI) artery. These vessels originate from the superficial palmar arterial arch as variant vessels as well as from the deep palmar arterial arch.

Influence of Sampling Site and Fluid Flow on the Accuracy of Total Body Clearance Calculation.

Studies have showed that by assuming arteriovenous drug concentrations are homogenous after intravenous injection, the determination of total body clearance based on venous drug concentrations is often inaccurate. This study considers the use of a fluidic pharmacokinetic profile generator where 28 different profile types were generated corresponding to a physiological model with varying sampling sites, administration locations, and fluid flow rates. Clearance was calculated using established equations, commercial software, and recently proposed models.

Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents.

The following work describes the development of a novel noninvasive transmucosal drug delivery system, the chitosan sponge matrix (CSM). It is composed of cationic chitosan (CS) nanoparticles (NPs) that encapsulate cisplatin (CDDP) embedded within a polymeric mucoadhesive CS matrix. CSM is designed to swell up when exposed to moisture, facilitating release of the NPs via diffusion across the matrix.