Publications by authors named "Brandon K Hilliard"
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) enzymes and are ubiquitously used for their anti-inflammatory properties. However, COX inhibition alone fails to explain numerous clinical outcomes of NSAID usage. Screening commonly used NSAIDs in primary human and murine myeloid cells demonstrated that NSAIDs could be differentiated by their ability to induce growth/differentiation factor 15 (GDF15), independent of COX specificity.
View Article and Find Full Text PDFCoronaviruses are a major health care threat to humankind. Currently, the host factors that contribute to limit disease severity in healthy young patients are not well defined. Interferons are key antiviral molecules, especially type I and type III interferons.
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- - Aging significantly increases the risk of severe COVID-19 due to factors like uncontrolled inflammation and weakened immune responses, as shown in a mouse model of infection using the MHV-A59 strain.
- - Infected older mice displayed higher mortality rates and systemic inflammation in key areas such as the heart and lungs, marked by neutrophilia and reduction of a specific immune cell type (γδ T cells).
- - A ketogenic diet was found to protect aged mice from severe infection by reducing inflammation and restoring the presence of γδ T cells, highlighting its potential as a treatment strategy for elderly patients with COVID-19.
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. We found that inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis.
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