Trio RNA sequencing in a cohort of medically complex children.

Genome sequencing (GS) is a powerful test for the diagnosis of rare genetic disorders. Although GS can enumerate most non-coding variation, determining which non-coding variants are disease-causing is challenging. RNA sequencing (RNA-seq) has emerged as an important tool to help address this issue, but its diagnostic utility remains understudied, and the added value of a trio design is unknown.

Correction: Klentrou et al. Circulating Levels of Bone Markers after Short-Term Intense Training with Increased Dairy Consumption in Adolescent Female Athletes. 2021, , 961.

There was an error in the original publication [...

Correction: McKinlay et al. Effects of Post-Exercise Whey Protein Consumption on Recovery Indices in Adolescent Swimmers. 2020, , 7761.

The authors of "Effects of Post-Exercise Whey Protein Consumption on Recovery Indices in Adolescent Swimmers" report an error in Table 1 of their article [...

Bone Turnover Markers and Osteokines in Adolescent Female Athletes of High- and Low-Impact Sports Compared With Nonathletic Controls.

This study examined differences in resting concentrations of markers of bone formation and resorption, and osteokines between female adolescent (12-16 y) swimmers, soccer players, and nonathletic controls. Resting, morning blood samples were obtained after an overnight fast from 20 swimmers, 20 soccer players, and 20 nonathletic controls, matched for age. carboxyl-terminal cross-linking telopeptide of type I collagen (CTX), amino-terminal propeptide of type I collagen (P1NP), total osteocalcin (OC), sclerostin, osteoprotegerin (OPG), and receptor activator of nuclear factor kappa B ligand (RANKL) were analyzed in serum.

Intensified training in adolescent female athletes: a crossover study of Greek yogurt effects on indices of recovery.

Background: During a period of intensified exercise (e.g. training/identification camps), often undertaken by competitive youth athletes, the maintenance of muscle function and peak performance can become challenging due to an accumulation of fatigue.

Circulating Levels of Bone Markers after Short-Term Intense Training with Increased Dairy Consumption in Adolescent Female Athletes.

Thirteen female adolescent soccer players (14.3 ± 1.3 years) participated in a cross-over, double-blind trial examining the effects of Greek yogurt (GY) consumption on bone biomarkers during 5 days of intense soccer training.

Cytokine concentrations in saliva vs. plasma at rest and in response to intense exercise in adolescent athletes.

Background: Salivary measures are advantageous in conducting large paediatric studies involving repeated measures. However, research measuring salivary cytokines in youth is limited.

Aim: Compare salivary with plasma concentrations of inflammatory cytokines at rest and following exercise in adolescent swimmers (21 male, 22 female).

Changes in Inflammatory Cytokines and Irisin in Response to High Intensity Swimming in Adolescent versus Adult Male Swimmers.

Swimming is a popular youth sport that is considered beneficial for cardiovascular fitness. However, the potential inflammatory outcomes of high intensity swimming in younger swimmers are unclear, as is the response of irisin, a myokine released during exercise with anti-inflammatory properties. This study compared the plasma concentrations of interleukins 1-beta (IL-1β), 6 (IL-6), 10 (IL-10), tumor necrosis factor alpha (TNF-α) and irisin in response to intense swimming between adolescent and adult male swimmers.

Effects of Post-Exercise Whey Protein Consumption on Recovery Indices in Adolescent Swimmers.

: This study examined the effect of whey protein consumption following high-intensity interval swimming (HIIS) on muscle damage, inflammatory cytokines and performance in adolescent swimmers. : Fifty-four swimmers (11-17 years-old) were stratified by age, sex and body mass to a whey protein (PRO), isoenergetic carbohydrate (CHO) or a water/placebo (HO) group. Following baseline blood samples (06:00 h) and a standardised breakfast, participants performed a maximal 200 m swim, followed by HIIS.

Effects of post exercise protein supplementation on markers of bone turnover in adolescent swimmers.

Background: This study examined the effects of whey protein supplementation, compared with an isocaloric carbohydrate beverage and water, consumed immediately following an intense swimming trial on bone turnover in adolescent swimmers.

Methods: Fifty-eight (31 female, 27 male) swimmers (14.1 ± 0.

Salivary and Serum Concentrations of Cortisol and Testosterone at Rest and in Response to Intense Exercise in Boys Versus Men.

This study compared salivary and serum concentrations of testosterone and cortisol at rest and in response to intense multitask exercise in boys and men. Early morning saliva and venous blood samples were obtained before and 15 minutes after exercise from 30 competitive swimmers (15 boys, age 14.3 [1.

Effects of Plyometric and Resistance Training on Muscle Strength, Explosiveness, and Neuromuscular Function in Young Adolescent Soccer Players.

McKinlay, BJ, Wallace, P, Dotan, R, Long, D, Tokuno, C, Gabriel, D, and Falk, B. Effects of plyometric and resistance training on muscle strength, explosiveness, and neuromuscular function in young adolescent soccer players. J Strength Cond Res 32(11): 3039-3050, 2018-This study examined the effect of 8 weeks of free-weight resistance training (RT) and plyometric (PLYO) training on maximal strength, explosiveness, and jump performance compared with no added training (CON), in young male soccer players.

Isometric and dynamic strength and neuromuscular attributes as predictors of vertical jump performance in 11- to 13-year-old male athletes.

In explosive contractions, neural activation is a major factor in determining the rate of torque development, while the latter is an important determinant of jump performance. However, the contribution of neuromuscular activation and rate of torque development to jump performance in children and youth is unclear. The purpose of this study was to examine the relationships between the rate of neuromuscular activation, peak torque, rate of torque development, and jump performance in young male athletes.

Effects of Motivational Self-Talk on Endurance and Cognitive Performance in the Heat.

Purpose: We tested the effectiveness of a 2-wk motivational self-talk (MST) intervention-specific to heat tolerance-on endurance capacity and cognitive function in the heat.

Methods: Eighteen trained male (n = 14) and female (n = 4) cyclists randomly received 2 wk of MST training (n = 9) or a control regimen (CON, n = 9). The experimental protocol was a PRE/POST design consisting of 30 min of cycling at 60% peak power output (PPO) in the heat (35°C, 50% relative humidity, ~3.

Salivary cortisol and testosterone responses to resistance and plyometric exercise in 12- to 14-year-old boys.

This study examined changes in salivary testosterone and cortisol following resistance and plyometric exercise protocols in active boys. In a crossover experimental design, 26 peri-pubertal (12- to 14-year-old) soccer players performed 2 exercise trials in random order, on separate evenings, 1 week apart. Each trial included a 30 min control session followed by 30 min of either resistance or plyometric exercise.