Pulmonary biomarkers based on alterations in protein expression after exposure to arsenic.

Objective: Environmental exposure to arsenic results in multiple adverse effects in the lung. Our objective was to identify potential pulmonary protein biomarkers in the lung-lining fluid of mice chronically exposed to low-dose As and to validate these protein changes in human populations exposed to As.

Methods: Mice were administered 10 or 50 ppb As (sodium arsenite) in their drinking water for 4 weeks.