Corneal collagen cross-linking: an introduction and literature review.

Background: This literature review analyzes the scientific evidence available regarding corneal collagen cross-linking (CXL) as a treatment option for progressive keratectasia.

Methods: A literature search was performed using dates from 1990 to August 2010 regarding CXL Specific areas of focus for the literature review include safety and efficacy of the procedure as a stand-alone treatment or when used in conjunction with Intacs® corneal implants (Addition Technology™) or photorefractive keratectomy (PRK).

Results: A total of 50 clinical trials and studies were identified, 20 of which met the inclusion criteria.