Publications by authors named "Brandon Hogland"
Relapsing fever (RF), a vector-borne disease caused by Borrelia spp., is characterized by recurring febrile episodes due to repeated bouts of bacteremia. RF spirochetes can be geographically and phylogenetically divided into two distinct groups; Old World RF Borrelia (found in Africa, Asia, and Europe) and New World RF Borrelia (found in the Americas).
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- The bacterium in question uses type III-secreted effector proteins to dodge host defenses, including a specific protein called OspC3 that inhibits the activity of caspase-11, which plays a role in immune responses against cytosolic bacteria.
- OspC3 has been shown to specifically bind to and inhibit primed caspase-11, preventing it from triggering pyroptosis (a form of programmed cell death) in neutrophils, which would help eliminate the bacterial threat.
- The study concludes that this inhibition allows the bacteria to survive and spread within the host, demonstrating that OspC3 can suppress the detection of cytosolic lipopolysacchar